Urinary enzymes in nephrotic syndrome |
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| Authors: | Sushant Chavan Nivrutti Hase Padma Chavan |
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| Institution: | (1) Department of Biochemistry, Lokmanua. Tilak. Municipal Medical College and General Hospital, Sion, 400 022 Mumbai, India;(2) Department of Medicine, Lokmanya. Tilak. Municipal. Medical College and General Hospital, Sion, 400 022 Mumbai, India |
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| Abstract: | Tubular damage is a complication associated with nephrotic syndrome and increased levels of urinary enzymes are of significant
value in detection of the same. The aim of our study was to evaluate the use of urinary lysozyme and trehalase as markers
of tubular dysfunction in nephrotic syndrome. This study assessed 35 nephrotic syndrome patients and 30 healthy controls matched
for age and sex. Urine samples were examined at pretreatment and post treatment (8 weeks) stages for proteinuria, lysozyme
and trehalase. At pretreatmant stage there was significant increase in urinary lysozyme and trehalase as compared to controls
(p<0.001). A good correlation was observed between degree of proteinuria and urinary lysozyme (p<0.001;r=0.80) and trehalase
(p<0.001; r=0.74). At the end of 8 weeks of treatment, the patients showed significant decrease in their urinary lysozyme
and trehalase activity (p<0.001) but no correlation with degree of proteinuria was observed. Our results indicate that enzymes
like lysozyme and trehalase can be used as markers of tubular dysfunction. |
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| Keywords: | Lysozyme Nephrotic syndrome Trehalase |
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