Reversible suppression of nitric oxide system in essential hypertension |
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| Authors: | M Chandra D R Maurya S Kumar H Basara A Ghatak B L Tekwani G Kaur M K Misra |
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| Institution: | (1) ICU, Department of Medicine, King George's Medical College, Lucknow University, Lucknow, India;(2) Division of Clinical Experimental Medicine, Lucknow University, Lucknow, India;(3) Division of Biochemistry, Central Drug Research Institute, Lucknow University, Lucknow, India;(4) Department of Biochemistry, University of Lucknow, 226 007 Lucknow, India |
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| Abstract: | Despite enormous research in the field of hypertension, its pathophysiology still remains largely unresolved and appears to
be multifactorial. In the present communication, we have analyzed the status of nitric oxide (NO) in the patients with essential
hypertension and age matched controls. We have found that the levels of NO are lowered in essential hypertension. The normalization
of blood pressure by administration of antihypertensive therapy causes rise in the NO level indicating that perturbed NO status
in essential hypertension is reversible. Addition of antioxidant to the antihypertensive drugs causes a further, though non
significant, rise in the levels of NO, suggesting that antioxidants may be combined with antihypertensive drugs as adjunct
in the management of essential hypertension. |
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| Keywords: | Nitric oxide Essential hypertension Antihypertensive treatment Antioxidants |
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