| Non-Isothermal Kinetics of Thermal Decomposition of a Novel Antitumor Agent 4-{5-[3,4-Dimethyl-5-（3,4,5 -Trimethoxyphenyl ）Thiophen-2-yl]-2-Methoxyphenyl}Morpholine |
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| 引用本文： | 雷英杰,石继仙,俞玫.Non-Isothermal Kinetics of Thermal Decomposition of a Novel Antitumor Agent 4-{5-[3,4-Dimethyl-5-（3,4,5 -Trimethoxyphenyl ）Thiophen-2-yl]-2-Methoxyphenyl}Morpholine[J].天津大学学报(英文版),2006,12(1):46-49. |
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| 作者姓名： | 雷英杰 石继仙 俞玫 |
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| 作者单位： | SCHOOL OF PHARMACEUTICALS AND BIOTECHNOLOGY TIANJIN UNIVERSITY TIANJIN 300072，CHINA，SCHOOL OF BIOTECHNOLOGY AND CHEMICAL ENGINEERING，TIANJIN UNIVERSITY OF TECHNOLOGY，TIANJIN 300191，CHINA，SCHOOL OF PHARMACEUTICALS AND BIOTECHNOLOGY TIANJIN UNIVERSITY，TIANJIN 300072，CHINA，SCHOOL OF PHARMACEUTICALS AND BIOTECHNOLOGY TIANJIN UNIVERSITY，TIANJIN 300072，CHINA |
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| 摘 要： | IN REEENT YEARS，MUEH ATTENTION HAS BEEN PAID TO DIARYL一SUBSTITUTED HETEROEYELES THAT ARE ASSOEIATED WITH HIGH BIOLOGIEAL AETIVITIES AS SELEETIVE COX一2 INHIBI- TORSL〕AND ANRITUMOR AGENTS21.A NEW EOM卯UND， NAMELY4一{5一3，4一DIMETHYL一5一(3，4，5一T
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| 关 键 词： | 抗肿瘤药 热分解 非等温动力学 4-{5-[3 4-二甲基-5-（3 4 5-三甲氧苯基）噻吩-2-基]-2-甲氧苯基}吗啉 |
| 收稿时间： | 2005-07-15 |
Non-Isothermal Kinetics of Thermal Decomposition of a Novel Antitumor Agent 4- {5- [3,4-Dimethyl-5- (3,4,5-Trimethoxyphenyl) Thiophen-2-yl] -2- Methoxyphenyl} Morpholine |
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| LEI Yingjie,SHI Jixian,YU Mei.Non-Isothermal Kinetics of Thermal Decomposition of a Novel Antitumor Agent 4- {5- [3,4-Dimethyl-5- (3,4,5-Trimethoxyphenyl) Thiophen-2-yl] -2- Methoxyphenyl} Morpholine[J].Transactions of Tianjin University,2006,12(1):46-49. |
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| Authors: | LEI Yingjie SHI Jixian YU Mei |
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| Abstract: | The thermal decomposition of a new antitumor agent. 4-5- 3,4-dimethyl-5-(3,4,5-trime-thoxyphenyl)thiophen-2-yl -2-methoxyphenyl morpholine was studied by Differential Scanning Cal-orimetry (DSC) and Thermogravimetry (TG)/ Derivative Thermogravimetry (DIG) methods at a flow rate of nitrogen gas of 120 mL/min. The kinetic parameters were obtained from the analysis of the corresponding curves by Kissinger's method, Ozawa's method and the integral method. The results indicate that the apparent activation energy and pre-exponential constants of the decomposition reaction are 106.67 kJ/mol and l06.19 s-1, respectively. |
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| Keywords: | 4-{5-[3 4-dimethyl-5-( 3 4 5-trimethoxyphenyl ) thiophen-2-yl] -2-methoxyphenyl} morpholine thermal decomposition kinetics |
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