| 地拉韦啶的关键中间体5-硝基-1H-吲哚-2-羧酸的合成工艺研究 |
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| 引用本文： | 何晓强,解海.地拉韦啶的关键中间体5-硝基-1H-吲哚-2-羧酸的合成工艺研究[J].雁北师范学院学报,2007,23(2):52-54. |
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| 作者姓名： | 何晓强 解海 |
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| 作者单位： | 1. 荆门职业技术学院化工系,湖北荆门,448000
2. 山西大同大学化学化工学院,山西大同,037009 |
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| 摘 要： | 以对硝基苯胺为原料,经重氮化、成腙、环合、水解等四个步骤得到抗艾滋病药物地拉韦啶的关键中间体5-硝基-1H-吲哚-2-羧酸,产物结构经1HNMR以及元素分析得到确证,总收率为59.0%.
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| 关 键 词： | 非核苷类逆转录酶抑制剂 甲磺酸地拉韦啶 中间体 合成 |
| 文章编号： | 1009-1939（2007）02-0052-03 |
| 修稿时间： | 2007-04-10 |
The Research of Synthesis Process of Delavirdine Intermediate 5-nitro-1H-indole-2-acid |
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| HE Xiao-qiang,XIE Hai.The Research of Synthesis Process of Delavirdine Intermediate 5-nitro-1H-indole-2-acid[J].Journal of Yanbei Teachers College,2007,23(2):52-54. |
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| Authors: | HE Xiao-qiang XIE Hai |
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| Institution: | 1. Depatment of Chemical Engineering, Jingmen Technical College, Jingmen Hubei , 448000; 2. College of Chemistry and Chemical Enhineering Shanxi Datong University,Shanxi Datong,037009 |
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| Abstract: | 5-nitro-lH-indole-2-acid as the mediate of anti-aids medicine delavirdine was obtained from p-nitroaniline 1 through diazotization.hydrazone reaction,cyclic reaction and hydrolysis,the yield was 59.0% ,its structure was measured with HNMR and elementary analyses, significantly it is easy to come true industrialization |
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| Keywords: | NNRTls delavirdine mesylate intermediate synthetic |
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