Alteration in some antioxidant enzymes in cardiac tissue upon monosodium glutamate [MSG] administration to adult male mice |
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| Authors: | Kuldip Singh Ahluwalia Pushpa |
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| Institution: | (1) Department of Biochemistry, Govt. Medical College, 143001 Amritsar, India;(2) Department of Biochemistry, Panjab University, 160014 Chandigarh, India |
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| Abstract: | 4mg and 8mg monosodium glutamate per gram body weight was administered subcutaneously for 6 consecutive days to normal adult
male mice and its effect was seen on 31st day after the last injection on some antioxidant enzymes in heart. A significant dose dependent increase in lipid peroxidation
and xanthine oxidase level was observed, whereas the activity of free radical scavenging enzymes such as superoxide dismutase
and catalase was decreased in both monosodium glutamate treated groups (Group-2 and Group-3). So, the present work suggested
that monosodium glutamate at dose level of 4mg/g body weight and above induced oxidative stress in the cardiac tissue by changing
the activity of free radical initiating enzyme such as xanthine oxidase and scavenging enzymes like superoxide dismutase and
catalase. |
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| Keywords: | Monosodium glutamate (MSG) Coronary heart disease (CHD) Atherosclerosis oxidative stress Hyperlipidemia and Lipid Peroxidation (LPO) |
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