Levels of plasma soluble complement receptor 1 (sCR1) in normal Indian adult population |
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| Authors: | B Sivasankar K R Raju V Anand S Malu S Padmanabhan S C Tiwari Nibhriti Das L M Srivastava |
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| Institution: | (1) Department of Biochemistry, All India Institute of Medical Sciences, 110 029 New Delhi, INDIA;(2) Department of Nephrology, All India Institute of Medical Sciences, 110 029 New Delhi, INDIA |
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| Abstract: | A decrease in the membrane anchored erythrocyte complement receptor 1 (CR1) is reported as an acquired phenomenon in a number
of inflammatory and autoimmune diseases with concomitant rise in soluble CR1 (sCR1) levels in plasma. There is a need to establish
the normal range of sCR1 in Indian adults to assess the function and disease association of this protein. The plasma sCR1
levels of 50 healthy individuals have been estimated by an indigenously developed sandwich ELISA. sCR1 levels from 26 patients
suffering from nephropathies had also been assayed which was much higher than the normal controls. This observation suggests
sCR1 as a potential market for the assessment of disease activity in nephropathies. |
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| Keywords: | Soluble complement receptor 1 Renal diseases Prognostic marker |
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