| Activity optimization method in SPECT： A comparison with ROC analysisActivity optimization method in SPECT： A comparison with ROC analysis |
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| 引用本文： | Díaz MP,Rizo OD,Díaz AL,Aparicio EE,Díaz RR.Activity optimization method in SPECT： A comparison with ROC analysisActivity optimization method in SPECT： A comparison with ROC analysis[J].浙江大学学报(B卷英文版),2006,7(12):947-956. |
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| 作者姓名： | Díaz MP Rizo OD Díaz AL Aparicio EE Díaz RR |
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| 摘 要： | A discriminant method for optimizing activity in nuclear medicine studies is validated by comparison with ROC （received operating characteristic）-curves. The method is tested in 21 single photon emission computerized tomography （SPECT）, performed with a cardiac phantom. Three different lesions （Lb L2 and L3） were placed in the myocardium-wall by pairs fbr each SPECT. Three activities （84, 37 or 18.5 MBq） of 99mTc were used as background. Linear discriminant analysis was used to select the parameters that characterize image quality among the measured variables in the images （Background-to-Lesion （B/Li） and Signal-to-Noise （S/N） ratios）]. Two clusters with different image quality （P=0.021 ） were obtained. The ratios B/Lj, B/L2 and B/L3 are the parameters used to construct the function with 100% of cases correctly classified into the clusters. The value of 37 MBq was the lowest tested activity for which good results for the B/Li ratios were obtained. The result coincides with the applied ROC-analysis （r=0.89）.
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| 关 键 词： | 活度优化 图像质量 SPECT 判别式分析 ROC曲线 |
| 收稿时间： | 2006-08-11 |
| 修稿时间： | 2006-09-14 |
Activity optimization method in SPECT: A comparison with ROC analysis |
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| Marlén Pérez Díaz,Oscar Díaz Rizo,Adlin López Díaz,Eric Estévez Aparicio,Reinaldo Roque Díaz.Activity optimization method in SPECT: A comparison with ROC analysis[J].Journal of Zhejiang University Science,2006,7(12):947-956. |
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| Authors: | Marlén Pérez Díaz Oscar Díaz Rizo Adlin López Díaz Eric Estévez Aparicio Reinaldo Roque Díaz |
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| Institution: | (1) Center for Studies on Electronics & Info Tech. Images Group, Central University of Las Villas, Santa Clara, 54830, Cuba;(2) Department of Nuclear Physics, Institute for Sciences and Advanced Technology, Havana, 10400, Cuba;(3) Department of Nuclear Medicine, Cardiovascular Surgery Institute, Havana, 10400, Cuba;(4) Department of Nuclear Medicine, University Hospital Celestino Hernández, Santa Clara, 50200, Cuba |
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| Abstract: | A discriminant method for optimizing activity in nuclear medicine studies is validated by comparison with ROC (received operating
characteristic)-curves. The method is tested in 21 single photon emission computerized tomography (SPECT), performed with
a cardiac phantom. Three different lesions (L
1
, L
2 and L
3) were placed in the myocardium-wall by pairs for each SPECT. Three activities (84, 37 or 18.5 MBq) of 99mTc were used as
background. Linear discriminant analysis was used to select the parameters that characterize image quality among the measured
variables in the images (Background-to-Lesion (B/L
i
) and Signal-to-Noise (S
i
/N) ratios)]. Two clusters with different image quality (P=0.021) were obtained. The ratios B/L
1
, B/L
2 and B/L
3 are the parameters used to construct the function with 100% of cases correctly classified into the clusters. The value of
37 MBq was the lowest tested activity for which good results for the B/L
i
ratios were obtained. The result coincides with the applied ROC-analysis (r=0.89).
Project supported by the Third World Academy of Sciences (TWAS), Cuba |
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| Keywords: | Activity optimization Image quality SPECT Discriminant analysis ROC curves |
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