| 血管内膜增生的机制研究进展 |
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| 引用本文： | 魏立春,邢壮杰,赵晖,郝国强.血管内膜增生的机制研究进展[J].大连大学学报,2010,31(6):92-95. |
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| 作者姓名： | 魏立春 邢壮杰 赵晖 郝国强 |
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| 作者单位： | 大连大学附属中山医院,辽宁大连116001 |
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| 摘 要： | 血管内膜增生是动脉粥样硬化和血管成形术后再狭窄等心血管疾病共同的生理特征,与血管重塑关系密切,防止内膜增生及术后再狭窄一直是国内外研究的重要课题。为从不同水平研究血管内膜增生发病的机制,给临床针对病因治疗提供依据,本文将从内皮损伤与功能障碍、脂质沉积、炎症反应、血管平滑肌细胞向内膜迁移、增殖及合成大量细胞外基质、基因改变等多种机制的研究方向,总结近些年来的研究成果,同时指出未来将在基因水平（如IGF-1 mRNA）、细胞生物学水平（如VSMC）及分子生物学水平（如内皮抑素、CRP）等各种研究方面有望成为新的研究突破点。
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| 关 键 词： | 内膜增生 动脉硬化 管腔狭窄 机制 |
Research Progress on Mechanism of Vascular Intima Hyperplasia |
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| WEI Li-chun,XING Zhuang-jie,ZHAO Hui,HAO Guo-qiang.Research Progress on Mechanism of Vascular Intima Hyperplasia[J].Journal of Dalian University,2010,31(6):92-95. |
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| Authors: | WEI Li-chun XING Zhuang-jie ZHAO Hui HAO Guo-qiang |
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| Institution: | (Department of Vascular Surgery,Zhongshan Affiliated Hospital,Dalian University,Dalian,116001,China) |
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| Abstract: | Vascular endometrial hyperplasia is common physiological characteristic of Cardiovascular diseases,such as Arteriosclerosis and restenosis after angioplasty and so on.It has close relationship with vascular remodeling.Preventing intimal proliferation and postoperative restenosis has always been an important subject of researching at home and abroad.To research the mechanism on vascular intima hyperplasia from different levels,and provide a basis for clinical aiming at etiological treatment,this paper aims at summarizing research achievements in recent years from researching direction of various mechanism about endothelial injury and dysfunction,lipid deposition,inflammatory reaction,vascular smooth muscle cell proliferation and migration to endometriosis,synthesis of extracellular matrix,genetic changes etc.The paper also points out the future on the genetic level(such as IGF-1 mRNA),cell biology level(such as VSMC) and the level of molecular biology(such as Endostatin,CRP) and other various research aspects.These are expected to become the new research fields. |
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| Keywords: | Endometrial Hyperplasia Arteriosclerosis Luminal Stenosis Mechanism |
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