| 复方金银花、茵陈五苓注射液对家兔内毒素性肾衰组织结构影响 |
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| 引用本文： | 周金星,李升和,冯保明.复方金银花、茵陈五苓注射液对家兔内毒素性肾衰组织结构影响[J].安徽科技学院学报,2012,26(2):6-10. |
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| 作者姓名： | 周金星 李升和 冯保明 |
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| 作者单位： | 安徽科技学院动物科学学院,安徽风阳,233100;安徽科技学院动物科学学院,安徽风阳,233100;安徽科技学院动物科学学院,安徽风阳,233100 |
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| 基金项目： | 安徽省教育厅自然科学研究项目，安徽省科技学院重点学科 |
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| 摘 要： | 目的:研究复方金银花和茵陈五苓两种注射液对内毒素所致家兔肾衰中肾脏组织结构的保护作用。方法:将重量2.5±0.25kg的健康雄性家兔32只,随机分为对照组、模型组、复方金银花组和茵陈五苓组,每组8只。模型组、复方金银花组、茵陈五苓组家兔一次性静脉注射大肠杆菌O111B4内毒素生理盐水,剂量为100ug/kg。两保护组家兔注射内毒素24h后静脉注射剂量为100ug/kg的中药注射液。模型组家兔静脉注射同容积的生理盐水。对照组家兔静脉注射与内毒素溶液和中药注射剂等体积的生理盐水。静脉注射内毒素及生理盐水后第7h处死。取肾组织标本,Bouns液固定,石蜡切片,HE染色,显微观察并摄影。结果:模型组肾脏肾小体血管球肿胀,有血栓形成,肾小囊壁层内皮细胞脱落,肾小囊腔变小,肾小管内皮细胞脱落。复方金银花组、茵陈五苓组肾脏的肾小体血管球略有肿胀,肾小囊的内皮细胞较完整,肾小囊腔较对照组稍变小。结论:复方金银花与茵陈五苓对家兔因内毒素所致肾衰中肾脏组织结构有确实的保护作用。
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| 关 键 词： | 复方金银花 茵陈五苓 肾脏 家兔 组织结构 |
Effect of Compound Honeysuckle and Herba Artemisiae Scoparia Injection on Tissue Structure of Endotoxin - Induced Acute Renal Failure in Rabbits |
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| ZHOU Jin-xing,LI Sheng-he,FENG Bao-ming.Effect of Compound Honeysuckle and Herba Artemisiae Scoparia Injection on Tissue Structure of Endotoxin - Induced Acute Renal Failure in Rabbits[J].Journal of Anhui Science and Technology University,2012,26(2):6-10. |
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| Authors: | ZHOU Jin-xing LI Sheng-he FENG Bao-ming |
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| Institution: | (College of Animal Science,Anhui Science and Technology University,Fengyang 233100,China) |
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| Abstract: | It is to study the effect of compound Honeysuckle and Herba Artemisiae Scoparia injection on tissue structure of endotoxin-induced Acute Renal Failure.Methods are as follows: 32 rabbits were randomly divided into 4 groups,the comparison group,the model group,compound honeysuckle group and Herba Artemisiae Scoparia group,each group had 8.The rabbits of model and each protective groups were given an intravenous injection of E.coli O111B4 endotoxin solution with dose of 100ug/kg.After injection of endotoxin,the two protective groups were injected compound honeysuckle and Herba Artemisiae Scoparia with intravenous injection,with the dose of 100g/kg respectively.The negative comparison group were injected just the right quantities of normal saline additionally.They were killed after intravenous injection of endotoxin and normal saline in 7h.Tissue samples from kidney,Where bouns liquid fixed,paraffin-embedded sliced,for HE staining,microscopic observation and photography.The kidney renal glomus body was swelling,and even and thrombosis.Renal endothelial wall was thin layer off,small renal cysts,renal tubular endothelial cell loss.The compound Honeysuckle group,Herba Artemisiae Scoparia group of renal corpuscle renal glomus was slight swelling,renal endothelial cells were smaller than the capsule integrity,and renal cysts is slightly smaller than the control group.The compound Honeysuckle and Herba Artemisiae Scoparia had a certain degree of protection on the renal structure dring to endotoxin-induced renal failure. |
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| Keywords: | Compound Honeysuckle Herba Artemisiae Scoparia Kidney Rabbits Tissue Structure |
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