Effect of dietary fish on the lipid profile of cholesterolstressed rats during copper overload |
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Authors: | M Nandini M Abdul Rahiman S Narasimha Rao |
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Institution: | (1) Department of Biochemistry, Kasturba Medical College, 575 001 Mangalore;(2) Dept. of Biosciences, Mangalore University, 574119 Mangalore;(3) University Medical Centre, 575001 Mangalore |
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Abstract: | The effect of dietary supplementation with Oil sardine (Sardinella longiceps) fish at 2/3 fat replacement, on serum lipids in the cholesterol-stressed copper loaded rats was studied. Hypercholesterolemic
state observed during copper toxicity was not alleviated by sardines. Copper loading significantly decreased the triglyceride
levels and the activity of β-hydroxy β-methyl glutaryl (HMG) CoA reductase. Fish supplementation was further effective in
reducing the triglyceride levels in copper loaded rats. Significant increase in the serum phospholipid was observed in the
fish supplemented rats during copper overload. The finding suggests that hypolipidemic potential of fish is certainly altered
to some extent in copper toxicity since, it is well known that copper enhances the formation of free radicals. Thus it may
be concluded that sardine fish is not effective in reducing the cholesterol levels during copper toxicity. |
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Keywords: | Sardine fish cholesterol-stress copper |
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