Conditioned taste aversion in Philippine rice rats (R. r. mindanensis): Comparisons among drugs,dosages, modes of administration,and sexes |
| |
| Authors: | Stephen A Shumake Ray T Sterner Stanley E Gaddis Kenneth A Crane |
| |
| Institution: | 1. Denver Wildlife Research Center, Building 16, Federal Center, 80225, Denver, Colorado
|
| |
| Abstract: | The effects of select drugs, dosages, and modes of administration upon learned taste aversions were compared among groups of wild-caught male and female Philippine rice rats (R. r. mindanensis). Experiment 1 compared two-choice saccharin aversions for 28 days among groups intubated with copper sulfate, cyclophosphamide, lithium chloride, red squill, sodium chloride (control), or deionized water (control). Main results were that 375 mg/kg lithium chloride produced the greatest sustained aversions, whereas 198 mg/kg cyclophosphamide and 210 mg/kg red squill produced moderate aversions, with males showing more resistance to extinction than females. Experiment 2 compared saccharin aversion among matched groups of male and female rats that received low (36 mg/kg), moderate (105 mg/kg), or high (368 mg/kg) dosages of lithium by gavage, ip injection, or ingestion. Sex differences in rates of extinction were found for the ingestion and injection-dosed rats, but no sex difference was again found for rats dosed by gavage. A significant mode × day interaction indicated that extinction progressed more rapidly for rats dosed by gavage. For all modes of administration, high dosages yielded intense 28-day aversion, moderate dosages produced intermediate 3–5 day aversion, and low dosages caused no aversion. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
