The effect of hepatic blood inflow occlusion on hepatic cancer treated with diode-laser thermocoagulation |
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| Authors: | Hong De-fei Li Song-ying Tong Li-min Chen Bin Peng Shu-you |
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| Institution: | Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China. hongdefi@mail.hz.zj.cn |
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| Abstract: | Objective: To assess the effect of temporary occlusion of hepatic blood inflow on hepatic cancer treated with diode-laser induced thermocogation (LITT). Methods: The carcinoma Walker-256 was implanted in 40 SD rat livers. Twelve days later, the animals were randomly divided into 4 groups. Group A received LITT alone; group B received hepatic artery temporary occlusion during LITT; group C received portal vein temporary occlusion during LITT; group D received hepatic artery and portal vein temporary occlusion during LITT. Tumors were exposed to 810 nm diode-laser light at 0.95 watts for 10 min from a scanner tip applicator placed in the tumor. At the same time, the intrahepatic temperature distribution in rats with liver tumors was measured per 2 min during thermocoagulation. Tumor control was examined immediately 7 and 14 d after thermocoagulation. Results:There was significant difference of intrahepatic temperature distribution in rats with liver tumors among the 4 groups (P＜0.05)except when group C samples were compared with group D samples at each time point, and group B samples were compared with group C samples at 120 s (P＞0.05). Light microscopic examination of the histologic section samples revealed three separate zones:regular hyperthermic coagulation necrosis zone, transition zone and reference zone. Compared with the samples in group A and group B, group C and group D samples had more clear margin among the three zones. Conclusion: The hepatic blood inflow occlusion, especially portal vein hepatic blood inflow occlusion, or all hepatic blood inflow occlusion considerably increased the efficacy of LITT in the treatment of liver cancer. |
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| Keywords: | Hepatic carcinoma/thermotherapy Laser/diode-laser Hepatic blood inflow/occlusion |
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