Biochemical and genetic studies on cardiometabolic syndrome |
| |
| Authors: | A Supriya Simon D Dinesh Roy V Jayapal T Vijayakumar |
| |
| Institution: | (1) Department of Cardiology, St. Antonius Hospital, Koekoekslaan 1, PO Box 2500, 3430 EM Nieuwegein, The Netherlands |
| |
| Abstract: | Cardiometabolic syndrome is one of the major public health issues of this century which describes a cluster of clinical characteristics.
Seventy two patients with coronary artery disease (CAD) and cardiometabolic syndrome and forty healthy age and sex matched
normal controls were selected for this study. Detailed clinical epidemiological and anthropometric characteristics were noted.
Lipid profile and Cytokinesis-block micronuclei (CBMN) assay using cytochalasin B were carried out in all the subjects. Serum
total cholesterol, triglyceride and LDL-cholesterol was significantly higher and HDL cholesterol was significantly lower in
patients compared to their normal counter-parts (P<0.05). CBMN frequency of the patients was significantly higher at all ages
compared to their normal counter parts (P<0.05). Various risk factors like diabetes, hypertension, dyslipidemia, abdominal
obesity, smoking and alcoholism were found influenced the CBMN frequency; but the changes were not significant. From this
study it can be concluded that DNA damage was found to be higher in patients with cardiometabolic syndrome which may be attributed
to the generation of free radicals associated with alcohol consumption, tobacco use, dyslipidemia and glucose intolerance
and the accumulation of free radicals with increase in age. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
