Somatic DNA Damages in Cardiovascular Autonomic Neuropathy |
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| Authors: | A Supriya Simon D Dinesh Roy V Jayapal T Vijayakumar |
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| Institution: | (1) Department of Biochemistry, Pushpagiri Institute of Medical Sciences and Research Centre, Thiruvalla, Kerala, 689 101, India;(2) Genetika, Centre for Advanced Genetic Studies, Thiruvananthapuram, 695 024, Kerala, India;(3) Govt. General Hospital, Thiruvananthapuram, Kerala, India;(4) School of Health Sciences, Kannur University, Kannur, Kerala, India |
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| Abstract: | Cardiovascular autonomic neuropathy (CAN) is one of the most clinically significant complications of diabetes mellitus. Even
though many ethological factors have been attributed for the pathogenesis of this disease no attempts were made to correlate
DNA damage as a causative factor. Hence the present study was undertaken to asses the extent of somatic DNA damages by cytokinesis-block
micronuclei assay (CBMN). An attempt is also being made to correlate the habits and/or risk factors and socioeconomic status
with CAN. The CBMN frequency of 46 patients suffering from autonomic neuropathy was compared with that of 25 healthy age and
sex matched controls. All the subjects were suffering from type 2 diabetes for at least 8 years and have varying degrees of
coronary artery diseases. The mean CBMN frequency of the patients was statistically higher than that of the healthy control
subjects (P < 0.05). The CBMN frequency was found to be significantly altered in CAN patients who where physical inactivity and smoking.
A significant correlation could also be observed between CAN and smoking, diabetes mellitus, hypertension, dyslipidemia, abdominal
obesity, and physical activity. |
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| Keywords: | Autonomic neuropathy Cardiovascular autonomic neuropathy (CAN) DNA damage Cytokinesis-block micronuclei (CBMN) assay Coronary artery diseases (CAD) |
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