Plasma Fibronectin Concentration in Obese/Overweight Pregnant Women: A Possible Risk Factor for Preeclampsia |
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| Authors: | Itemobong S Ekaidem Debayo M Bolarin Alphonsus E Udoh Saturday J Etuk Christopher E J Udiong |
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| Institution: | (1) Department of Chemical Pathology, Faculty of Clinical Sciences, College of Health Science, University of Uyo, P.M.B. 1017, Uyo, Nigeria;(2) Department of Chemical Pathology, College of Medical Sciences, University of Calabar, Calabar, Nigeria;(3) Department of Obstetrics and Gynaecology, College of Medical Sciences, University of Calabar, Calabar, Nigeria |
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| Abstract: | Plasma fibronectin (FN) levels in obese/overweight and non-obese pregnant women were evaluated as a possible risk factor for
preeclampsia. A total of one hundred and sixty three pregnant women attending antenatal clinic at University of Calabar Teaching
Hospital participated in the study and sixty non-pregnant women served as control. About 77 (47.24%) of the pregnant women
were followed up for any subsequent development of preeclampsia during the pregnancy. Fibronectin levels in plasma were measured
by ELISA assay and serum total protein, urea and creatinine were determined spectrophotometrically. The mean plasma FN concentration
of non-obese pregnant women in first trimester was lower than those of the non-pregnant women by 24%, but however, increased
to the non-pregnant level in second and third trimesters. Obese/overweight pregnant women had significantly (P < 0.05) higher values than non-obese pregnant women in second and third trimesters. FN in obese/overweight pregnant women
correlated positively with mean arterial blood pressure (MAP: r = 0.414, P = 0.04). About 28.57% of the pregnant women with FN above cut off point of 330 μg/ml at 18–24 weeks of gestation developed
preeclampsia. This value increased to 40.0% when only the obese/overweight women were considered. On analysis of both fibronectin
>330 μg/ml and MAP > 90, the predictive value increased to 66.7%. We therefore conclude that elevated FN may be regarded as
a risk factor of preeclampsia especially among the obese women. |
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| Keywords: | Fibronectin Obesity Arterial pressure Risk factor Pregnancy Preeclampsia |
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