| 偏最小二乘法用于阿昔洛韦片的近红外漫反射快速、无损含量测定 |
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| 引用本文： | 周雨菁,相秉仁,王正武.偏最小二乘法用于阿昔洛韦片的近红外漫反射快速、无损含量测定[J].南京晓庄学院学报,2009,25(3):29-33. |
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| 作者姓名： | 周雨菁 相秉仁 王正武 |
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| 作者单位： | 1. 中国药科大学分析测试中心,江苏,南京,210009
2. 上海交通大学农业与生物学院食品工程系,上海,201101 |
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| 基金项目： | 国家自然科学基金，上海市科委标准化课题 |
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| 摘 要： | 目的:采用偏最小二乘法结合近红外漫反射光谱,建立阿昔洛韦片的快速无损含量测定模型.方法:以阿昔洛韦片为分析对象,用光纤探头测定近红外漫反射光谱.对光谱进行不同预处理方法建模并进行比较,多元校正模型为偏最小二乘法.结果:在11995.5～4246.7cm-1波长范围内采用一阶导数结合矢量归一化对光谱进行预处理,结果最优.定量模型的浓度范围为27%～53%.预示集平均回收率为98.69%,RSD为4.60%,RMSEP为0.0526.结论:近红外漫反射光谱法快速,简便,无损,能够用于阿昔洛韦片含量测定.
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| 关 键 词： | 近红外漫反射光谱 阿昔洛韦片 偏最小二乘法 含量测定 |
Rapid,Non-destructive Quantitative Determination of Acyclovir Tablets by NIR Combined with Partial Least Square |
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| ZHOU Yu-jing,XIANG Bing-ren,WANG Zheng-wu.Rapid,Non-destructive Quantitative Determination of Acyclovir Tablets by NIR Combined with Partial Least Square[J].Journal of Nanjing Xiaozhuang College,2009,25(3):29-33. |
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| Authors: | ZHOU Yu-jing XIANG Bing-ren WANG Zheng-wu |
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| Institution: | 1.Center for Instrumental Analysis;China Pharmaceutical University;Nanjing 210009;China;2.Department of Food Science Technology;School of Agriculture and Biology;Shanghai Jiaotong University;Shanghai 200240;China |
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| Abstract: | The present study is aimed to apply near-infrared reflectance(NIR) analysis combined with partial least square(PLS) in non-destructive content determination of acyclovir tablets.NIR spectra of acyclovir tablets were obtained by a fiber optic probe.Several methods were used for the pre-treatments of spectra and the comparison of the results.Spectral regions 11995.5~4246.7 cm-1 was selected to develop the mathematical models by PLS.It was found that the result was the best when pre-treated by first derivative... |
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| Keywords: | near-infrared diffuse reflectance spectrometry acyclovir tablet partial least square content determination |
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