Effect of Metformin on Hormonal and Biochemical Profile in PCOS Before and After Therapy |
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| Authors: | Bratati Singh Suchismita Panda Rachita Nanda Sanghamitra Pati Manaswini Mangaraj Pratima Kumari Sahu Prakash Chandra Mohapatra |
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| Institution: | (1) Department of Biochemistry, SCB Medical College, Cuttack, 753007, Orissa, India;(2) Department of Biochemistry, IMS & SUM Hospital, Siksha O Anusandhan University, Bhubaneswar, Orissa, 751003, India |
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| Abstract: | Insulin resistance and the resultant hyperinsulinemia exacerbate the reproductive abnormalities of Polycystic Ovarian Syndrome
by increasing ovarian androgen productions and decreasing serum sex hormone binding globulin. The present study was conducted
to estimate serum insulin and testosterone level in 44 PCOS cases and 32 control patients. Simultaneously the role of metformin
(an insulin sensitizing agent) in modulating insulin resistance and serum androgen level was also analyzed. A significant
rise in serum insulin and testosterone (P < 0.001) was observed in cases in comparison to control. Fasting Plasma Glucose to insulin ratio, a marker of insulin resistance
revealed a significant fall in PCOS group. Follow up of cases with metformin for 3 months revealed a significant fall in serum
insulin (P < 0.05) with improvement in insulin resistance along with a nonsignificant fall in testosterone level. Serum insulin registered
a significant positive correlation (P < 0.05) with serum testosterone revealing its etiological association. Thus administration of drugs ameliorating insulin
levels is expected to provide new therapeutic modality for PCOS. |
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| Keywords: | Polycystic ovarian syndrome Hyperandrogenism Metformin |
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