| Effects of vanadate on the activities of mice glucokinase and hexokinase |
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| 作者姓名： | 徐明智 张爱珍 李向荣 许唯 沈凌炜 |
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| 作者单位： | Department of Endocrinology，First Affiliated Hospital，College of Medicine，Zhejiang University，Hangzhou 310003，China，Medical Nutrition and Food Hygiene Graduate School，Zhejiang University，Hangzhou 310031，China，Division of Life Sciences，City College，Zhejiang University，Hangzhou 310015，China，Department of Isotopology，Second Affiliated Hospital，College of Medicine，Zhejiang University，Hangzhou 310009，China，Department of Isotopology，Second Affiliated Hospital，College of Medicine，Zhejiang University，Hangzhou 310009，China |
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| 摘 要： | This study aimed at acquiring knowledge on the hypoglycemic mechanisms of sodium metavanadate (SMV) showed that the liver glucokinase and muscle hexokinase activities increased rapidly after oral SMV was given, and that the blood glucose level was correlated closely with the activities of the two enzymes but not with the insulin level; which indicated that SMV could improve the altered glucose phosphorylation in diabetic mice independently of stimulating insulin secretion. This was probably one of the mechanisms of hypoglycemic effects of SMV.
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Effects of vanadate on the activities of mice glucokinase and hexokinase |
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| XUMing-zhi,ZHANG Ai-zhen,LI Xiang-rong,XU Wei,SHEN Ling-wei.Effects of vanadate on the activities of mice glucokinase and hexokinase[J].Journal of Zhejiang University Science,2004(10). |
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| Authors: | XUMing-zhi ZHANG Ai-zhen LI Xiang-rong XU Wei SHEN Ling-wei |
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| Abstract: | This study aimed at acquiring knowledge on the hypoglycemic mechanisms of sodium metavanadate (SMV) showed that the liver glucokinase and muscle hexokinase activities increased rapidly after oral SMV was given, and that the blood glucose level was correlated closely with the activities of the two enzymes but not with the insulin level; which indicated that SMV could improve the altered glucose phosphorylation in diabetic mice independently of stimulating insulin secretion. This was probably one of the mechanisms of hypoglycemic effects of SMV. |
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| Keywords: | Sodium metavanadate (SMV) Glucokinase Hexokinase Blood glucose Insulin |
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