A comparative study of tumor markers of adenocarcinoma prostate |
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| Authors: | A Saraswathi T Malati |
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| Institution: | 1. Department of Biochemistry, Nizam's Institute of Medical Sciences, 500 482, Hyderabad
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| Abstract: | The present study deals with the evaluation and comparison of the tumor markers for prostatic carcinoma—The Total Acid Phosphatase
(ACP Total) and its Prostatic Fraction (ACP PF) estimated by the enzyme kinetic method, an immunoreactive Prostatic Acid Phosphatase
(PAP) and Prostate Specific Antigen (PSA) estimated by enzyme immunoassay. The comparison of all four markers revealed that
there was no perfect positive correlation between any of these four markers. PSA had shown a better correlation with ACP Total
and its prostatic fraction ACP PF. No correlation was observed between PSA and PAP. Of the four markers PAP exhibited a very
low sensitivity, positive and negative predictive values. PSA had shown an absolute specificity, sensitivity, positive and
negative predictive values for adenocarcinoma prostate. PSA levels in all phases of disease showed a 100% correlation with
disease status. Being a marker with very high tissue specificity and sensitivity, it is revolutionizing the diagnosis of prostatic
carcinoma. Hence, it could be used effectively for screening of elderly people over 50 years of age who are at high risk for
developing prostatic carcinoma for early diagnosis of this disease. |
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| Keywords: | PSA PAP ACP ACP PF Tumor Markers |
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