Fractionated evaluation of immunohistochemical hormone receptor expression enhances prognostic prediction in breast cancer patients treated with tamoxifen as adjuvant therapy |
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| Authors: | Ching-hung Lin Huang-chun Lien Fu-chang Hu Yen-shen Lu Sung-hsin Kuo Ling-chu Wu San-lin You Ann-lii Cheng King-jen Chang and Chiun-sheng Huang |
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| Institution: | (1) University of Minnesota, Minneapolis, MN, USA;(2) Miami Veterans Affairs Healthcare System, Miami, FL, USA;(3) Remuda Program for Eating Disorders, Wickenburg, AZ, USA |
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| Abstract: | Objective: To compare the prognostic prediction between dichotomized and fractionated evaluations of hormone receptor expressions. Methods: Patients with stages Ⅰ-Ⅲ breast cancers, who received adjuvant tamoxifen, were enrolled. The expression of estrogen receptor (ER) and progesterone receptor (PR) was evaluated by immu-nohistochemistry (IHC). A fractionated score (F score), the percentage of positive-staining nuclei (0=none, 1=1%-10%, 2=11%-30%, 3=31%-50%, 4=51%-70%, and 5=71%-100%), was assigned to each case. The dichotomized scoring method defines an F score >1 as positive. The prognostic values of both scores were compared by multiple Cox's proportional hazard models of disease-free survival (DFS) and overall survival (OS). Results: Four hundred and six-teen patients with a median follow-up of 78.0 months were included. F scores for ER and PR correlated directly with DFS and OS. Although both the dichotomized and fractionated ER and PR scores were significantly associated with DFS and OS in univariate analyses, only fractionated ER and PR scores remained as independent prognostic factors of DFS and OS in the final multiple Cox's proportional hazard models. Conclusion: Fractionated IHC hormone receptor expression evaluation enhances the prognostic prediction compared with a dichotomized assessment. |
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| Keywords: | Breast cancer Fractionated evaluation Estrogen receptor Progesterone receptor |
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