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| 不同方式跑台运动对去卵巢小鼠破骨细胞分化及相关调节因子的影响 | |
| 引用本文： | 李世昌,季浏,马涛,罗剑,李珍惜,郑庆云.不同方式跑台运动对去卵巢小鼠破骨细胞分化及相关调节因子的影响[J].中国体育科技,2011,47(5). |
| 作者姓名： | 李世昌 季浏 马涛 罗剑 李珍惜 郑庆云 |
| 作者单位： | 1. “青少年健康评价与运动干预”教育部重点实验室,华东师范大学体育与健康学院,上海 200241 2. 浙江工业大学体育军训部,浙江 杭州,310014 3. 华东师范大学生命医学研究所,上海,200241 |
| 基金项目： | 国家社会科学基金重大项目(10ZD&052) |
| 摘 要： | 目的:以去卵巢小鼠模拟妇女绝经后骨质疏松症状,对比研究上、下坡跑台运动对去卵巢小鼠破骨细胞分化及相关调节因子的影响.方法:64只8周龄C57 BL/6雌性小鼠随机分为4组:假手术安静组(SHAM),去卵巢安静组(OVX),去卵巢上坡跑组(OVX +UP),去卵巢下坡跑组(OVX +DOWN).结果:与SHAM组相比,OVX组小鼠干细胞向巨噬细胞分化的能力、巨噬细胞向破骨细胞分化的能力均显著增强；骨组织RANKL、M-CSF和RANK的基因表达显著增加,而OPG的基因表达显著降低.与OVX组相比,两运动组小鼠破骨细胞的分化得到了较好的抑制.结论:跑台运动可有效抑制小鼠去卵巢后破骨细胞的大量分化,从而有利于预防骨质疏松症的发生,且下坡跑运动比上坡跑运动更有效. |
| 关 键 词： | 跑台运动 去卵巢小鼠 破骨细胞 分化 OPG-RANKL-RANK系统 |
Effect of Treadmill Exercise in Different Ways on Osteoclast Differentiation and Related Regulators in Ovariectomized Mice |
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| LI Shi-chang,JI Liu,MA Tao,LUO Jian,LI Zhen-xi,ZHENG Qing-yun.Effect of Treadmill Exercise in Different Ways on Osteoclast Differentiation and Related Regulators in Ovariectomized Mice[J].China Sport Science and Technology,2011,47(5). | |
| Authors: | LI Shi-chang JI Liu MA Tao LUO Jian LI Zhen-xi ZHENG Qing-yun |
| Institution: | LI Shi-chang1,JI Liu1,MA Tao2,LUO Jian3,LI Zhen-xi3,ZHENG Qing-yun11.Key Laboratory of Adolescent Health Assessment and Exercise Intervention,Ministry of Education,East China Normal University,Shanghai 200241,China,2.Physical Education and Military Department,Zhejiang University of Technology,Hangzhou 310014,3.Institute of Biomedical Sciences,China. |
| Abstract: | Objective:Through simulation in ovariectomized mice to women with postmenopausal osteoporosis,we compare effects of uphill and downhill running on osteoclast differentiation and related regulators in ovariectomized mice.Method:64 8-week-old C57 BL/6 female mice were randomly divided into 4 groups:sham operation group(SHAM),ovariectomized group(OVX),uphill running group(OVX+UP) and downhill running group(OVX+DOWN).Result:Compared with the SHAM group,the ability of stem cells differentiating into macrophage c... |
| Keywords: | treadmill exercise ovariectomized mice osteoclast differentiation OPG-RANKL-RANK system |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |