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| γ-连环素在大鼠舌部鳞状细胞癌癌变过程中的表达 | |
| 引用本文： | 张卫民,高岩,李迅.γ-连环素在大鼠舌部鳞状细胞癌癌变过程中的表达[J].大连大学学报,2007,28(3):102-104. |
| 作者姓名： | 张卫民 高岩 李迅 |
| 作者单位： | 1. 大连大学,医学院,辽宁,大连,116622 2. 北京大学,口腔医学院,北京,100081 3. 大连大学,电教中心,辽宁,大连,116622 |
| 基金项目： | 国家自然科学基金 , 大连大学校科研和教改项目 |
| 摘 要： | 目的]研究γ-连环素在大鼠舌部鳞状细胞癌中的表达,探讨其在口腔鳞状细胞癌癌变过程中的作用.方法]免疫组织化学方法检测48例不同分化程度大鼠舌部鳞状细胞癌中γ-连环素的表达.结果]γ-连环素在大鼠舌黏膜癌变过程中均有表达,表达部位在细胞膜,γ-连环素的表达与大鼠舌黏膜癌变过程中的组织学分级不具有显著性差异(P>0.05).结论]γ-连环素在大鼠舌黏膜癌变中具有一定作用. |
| 关 键 词： | γ-连环素 β-连环素 大鼠 癌变 鳞状细胞癌 |
| 文章编号： | 1008-2395（2007）03-0102-03 |
| 修稿时间： | 2006-10-262007-04-11 |
Roles of Gamma-Catenin in the Carcinogenesis of Squamous Cell Carcinoma in Rat Tongue |
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| ZHANG Wei-min,GAO Yan,LI Xun.Roles of Gamma-Catenin in the Carcinogenesis of Squamous Cell Carcinoma in Rat Tongue[J].Journal of Dalian University,2007,28(3):102-104. | |
| Authors: | ZHANG Wei-min GAO Yan LI Xun |
| Institution: | 1. Medical College of Dalian University,Dalian 116622, China; 2. College of Stomatology,Peking University,Beijing 100081, China; 3. Electrified Education Center,Dalian University,Dalian 116622 ,China |
| Abstract: | Objective]The role of gamma-catenin in the carcinogenesis of oral squamous cell carcinoma(OSCC) has not yet been elucidated.We investigated its expressions in OSCC,probing its role during the course of OSCC carcinogenesis.Methods]Surgical specimens from 48 OSCC rats were examined for gamma-catenin expression by the method of immunohistochemical staining.Results]During the carcinogensis of rat tongue almost all the cases showed membrane expressions of gamma-catenin.Gamma-catenin showed no significant difference with the grades of OSCC carcinogenesis in rats.Conclusions]The results suggested that gamma-catenin play an important role during the course of OSCC carcinogenesis. |
| Keywords: | gamma-catenin beta-catenin rat carcinognesis squamous cell carcinoma |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |