PCT as a Prognostic Marker in Cardiac Patients with Neutropenic Sepsis: Two Case Reports |
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| Authors: | Neelima Verma Shaloo Kapoor Deepa Rao Siddhartha Sharma Anita Arora |
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| Institution: | 1. Department of Clinical Biochemistry, Fortis Escorts Heart Institute, Okhla Road, New Delhi, India
2. Super Religare Laboratories, Fortis Escorts Heart Institute, New Delhi, India
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| Abstract: | Procalcitonin (PCT) is an innovative and highly specific marker for diagnosis of clinically relevant bacterial infection and sepsis. PCT supports early diagnosis and Clinical decision making. A retrospective study of two classical cases of neutropenic sepsis with elevated PCT levels in cardiac ICU was done. PCT was analyzed using Elecsys Brahms PCT kit. Serum PCT levels <0.5 ng/ml and ANC <1,000/mm3 was taken as cutoff. The first patient had initial high levels of PCT 100 ng/ml, TLC 13,600/mm3 and ANC 12,250/mm3. It was followed by drop with subsequent rise in PCT levels and drop in TLC 1,000/mm3 and ANC 70/mm3. The second patient had normal PCT 0.116 ng/ml, TLC 5,600/mm3 and ANC 4,420/mm3 levels followed with sharp increase in all the values with subsequent drop in TLC 2,000/mm3 and ANC 880 cells/mm3. Both the patients died of neutropenic sepsis with multiorgan failure. The case reports showed the correlation of PCT with TLC and ANC levels in predicting the mortality of patients with neutropenic sepsis in cardiac ICU. |
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| Keywords: | Procalcitonin Neutropenic sepsis Total leucocyte count Cardiac patients Absolute eosinophil count |
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