Maternal and fetal indicators of oxidative stress in various obstetric complications |
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| Authors: | Guruprasad Rao Ullas Kamath Chaerkadi Raghothama K Sujatha Pradeep Pragna Rao |
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| Institution: | (1) Department of Biochemistry, International Centre for Health Sciences and Kasturba Medical College, 576 119 Manipal, Karnataka, India;(2) Department of Obstetrics and Gynaecology, Kasturba Medical College, Manipal;(3) Department of Biochemistry, Kamineni Institute of Medical Sciences, Narketpally, Andhra Pradesh, India |
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| Abstract: | The present study demonstrates the incidence of increased lipid peroxidation and protein oxidation in both maternal and fetal
erythrocytes as markers of oxygen radical activity in different complications of pregnancy. In fetuses born after premature
rupture of membranes, lipid peroxidation was significantly elevated as indicated by increased malondialdehyde levels (p<0.05)
as compared to controls. Proteolytic activity in the erythrocytes of mothers in this group was also significantly high (p<0.01).
In patients delivered by lower segment cesarian section, lipid peroxidation and proteolytic activity in maternal erythrocytes
were significantly high (p<0.05 and p<0.001 respectively). In patients with prolonged second stage of labour, lipid peroxidation
and proteolytic activity in maternal erythrocytes was significantly higher than in controls (p<0.001 and p<0.05 respectively).
In this group, endogenous protein damage due to oxidative stress was significantly high both in the mother and the fetus (p<0.001
and p<0.05 respectively). |
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| Keywords: | Lower segment cesarian section malondialdehyde premature rupture of membranes prolonged second stage of labour proteolytic activity |
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