Studies on a new antitubercular drug, trifluoperazine: Its effect in combination with conventional antitubercular drugs in tubercular lymphadenitis |
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| Authors: | R L Gupta Sundeep Jain V Talwar H C Gupta P S Murthy |
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| Institution: | (1) Department of Surgery, University College of Medical Sciences and GTB Hospital, Shahdara, 110092 Delhi;(2) Department of Microbiology, University College of Medical Sciences and GTB Hospital, Shahdara, 110092 Delhi;(3) Department of Biochemistry, University College of Medical Sciences and GTB Hospital, Shahdara, 110092 Delhi;(4) Indian Journal of Clinical Biochemistry B164, Sector 14, 20131 Noida, UP |
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| Abstract: | After demonstrating that trifluoperazine (TFP) possesses invitro antitubercular activity against drug (single and multidrug) resistantMycobacterium tuberculosis, we initiated preliminary clinical studies in a few patients of tubercular lymphadenitis. Effect of TFP was assessed by testing
the antitubercular activity of the serum of patients receiving TFP in addition to regular therapy. Patients were divided into
two groups of 30 each. For ethical considerations, patients of both groups were treated initially for one month with antitubercular
therapy (ATT) consisting of isoniazid, rifampicin, ethambutol and pyrazinamide and TFP was tried for 15 days only. Patients
of group1 were given a single dose of TFP (5mg/day) daily from days 31 to 45 in addition to ATT, while those in group 2 received
ATT only. Assessment of the antitubercular activity of the serum (testedin vitro in Youmans and Karlson’s liquid medium) revealed that the serum of patients (collected on 45th day) of group1 (ATT+TFP treated)
possessed much higher antitubercular activity than that of group 2 (ATT only treated) patients. Clinical examination indicated
that overall improvement was seen much earlier in group1 (ATT+TFP) patients than in group 2 (ATT alone) patients. At the end
of the follow up period of 6 months with ATT from 46th day onwards to both groups, there were no side effects due to TFP.
Hematology and liver function tests were normal in both the groups. We suggest that TFP has good potential and therefore deserves
further studies either in combination with other drugs of ATT or as one of the drugs of ATT, for the treatment of tuberculosis
due to MDR strains to find a suitable effective dose without side effects. |
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| Keywords: | Trifluoperazine Antitubercular drug Tubercular lymphadenitis Tuberculosis chemotherapy |
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