The role of gene DCDC2 in German dyslexics |
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| Authors: | A Wilcke J Weissfuss H Kirsten G Wolfram J Boltze and P Ahnert |
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| Institution: | (1) Fraunhofer-Institute for Cell Therapy and Immunology, Perlickstr. 1, 04103 Leipzig, Germany;(2) IKIT—Institute for Clinical Immunology and Transfusion Medicine, University of Leipzig, Leipzig, Germany;(3) BBZ—Center for Biotechnology and Biomedicine, University of Leipzig, Leipzig, Germany;(4) TRM—Translational Center for Regenerative Medicine, University of Leipzig, Leipzig, Germany;(5) IMISE—Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany |
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| Abstract: | Dyslexia is a complex reading and writing disorder with a strong genetic component. In a German case-control cohort, we studied
the influence of the suspected dyslexia-associated gene DCDC2. For the first time in a German cohort, we describe association
of a 2445 basepair deletion, first identified in an American study. Evidence of association for three DCDC2 single nucleotide
polymorphisms (rs807724, rs793862, rs807701), previously identified in German or American cohorts, was replicated. A haplotype
of these polymorphisms showed evidence for association as well. Thus, our data further corroborate association of DCDC2 with
dyslexia. Analysis of functional subgroups suggests association of investigated DCDC2 variants mainly with nondysphonetic,
nonsevere, but probably dyseidetic (surface) dyslexia. Based on the presumed function of DCDC2, our findings point to a role
of impaired neuronal migration in the etiology of the disease.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users.
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| Keywords: | DCDC2 Genetics Genetics of dyslexia Germans Subgroups Subgroup-specificity |
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