| 运动心脏结构与功能的发生与转归 |
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| 引用本文： | 常芸,林福美.运动心脏结构与功能的发生与转归[J].山东体育科技,2000,22(1):40-48. |
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| 作者姓名： | 常芸 林福美 |
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| 作者单位： | 国家体育总局体育科研所 |
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| 摘 要： | 为了进一步探讨运动心脏结构与功能的发生、转归及其与病理心脏的本质差异，本通过动物实验模拟运动心脏，观察了经过１２周耐力训练及完全停止运动训练８周后心脏重量和超微结构的变化，应用激光扫描共聚焦显微镜与新一代钙荧光指示剂Ｆｌｕｏ－３／ＡＭ负载方法对心肌活动细胞内具有生物活性的游离钙的动态变化进行了研究。结果显示：经过１２周耐力训练后，心肌活细胞内游离钙浓度静息值无显性改变，心肌心缩时其游离钙浓度峰
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| 关 键 词： | 停止训练 运动心脏 细胞内游离钙 发生 转归 |
The Structural Development and Reversibility in Exercise Induced Heart Remodeling |
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| Chang Yun,Lin Fumei,ChenXiaotong,Luo Anming.The Structural Development and Reversibility in Exercise Induced Heart Remodeling[J].Shandong Sports Science & Technology,2000,22(1):40-48. |
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| Authors: | Chang Yun Lin Fumei ChenXiaotong Luo Anming |
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| Abstract: | In order to investigate the development and prognosis of exercise induced heart remodeling, the changes of the intracellularCa 2 ] were determined in single isolated ventricular myocyte under the laser scanning confocal microscopy. The myocardial ultrastructures were analyzed by computer image system. 80 male SD rats were randomly divided into endurance running group, deconditioning group and their sedentary controls. The results showed that, after training, there were no significant changes in myocardial Ca 2 ]i basal values, but the myocardial Ca 2 ]i peak values were significantly increased 11%. The atrial specific granule volume density, surface density and numerical density significantly increased 41%,12% and 5%, respectively; the myocardial mitochodria volume density and mitochodria to myofibrial ratio were significantly increased 61% and 60% respectively; the mitochodria inner membrance and cristea volume density significantly incresed 18%, the myocardial capillary to fiber ratio significantly incresed 78%; the myocardial capillary luminal volume density and surface density significantly increased 28% and 13%, respectively as compared with their controls (P<0.05). After deconditioning, the myocardial Ca 2 ]i peak values were significantly decreased 14%; the atrial specific granule volume density decreased 25%; the myocardial mitochodria volume density and mitochodria to myofibrial ratio were significantly decreased 25% and 36%, respectively; the mitochodria inner membrance and cristea volume density singnifcantly decresed 11%, the myocardial capillary to fiber ratio significantly decresed 78%; the myocaridal capillary luminal volume density and surface density significantly decreased 12% and 14%; respectively as compared with the conditioning group (P<0.05),and there were no significant differences with their controls. The results suggested that there was an intracellular calcium homeostasis in athletic haeart and the calcium supplement to myocardial contractile elements was increased while heart contraction. The myocardial ultrastructues prodeuced good adaptation. Those changes were an important mechanism for improved heart contractility, metabolism and self endocrine. And the elevated myocardial Ca 2 ]i peak level might be a signal linking between cardiac hormons and exercise induced cardiac hypertrophy. Also, the changes of myocardial Ca 2 ]i and myocardial ultrastructues were reversible while deconditioning. |
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| Keywords: | deconditioning athletic heart myocardial morphometry intracellular free calcium laser scanning confocal microscopy |
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