| N-甲酰-α-L-天门冬氨酰-L-苯丙氨酸水相合成法 |
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| 引用本文： | 吴江,叶发兵.N-甲酰-α-L-天门冬氨酰-L-苯丙氨酸水相合成法[J].黄冈师范学院学报,2013(6):30-31,39. |
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| 作者姓名： | 吴江 叶发兵 |
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| 作者单位： | [1]德纳（南京）化工有限公司,江苏南京210047 [2]黄冈师范学院化学化工学院,湖北黄州438000 |
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| 摘 要： | 将N-甲酰-α—L-天门冬氨酸酐和液碱分次加入L-苯丙氨酸的碱性水溶液中，实现N-甲酰-α—L-天门冬氨酸酐与L-苯丙氨酸的酰化反应，得到产物N-甲酰-α—L-天门冬氨酰-L-苯丙氨酸，产率达96％。该方法实现水相酰化，大幅降低生产成本，实现生产工艺的绿色化。
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| 关 键 词： | N-甲酰-α-L-天门冬氨酰-L-苯丙氨酸 水相合成 酰化 |
N -- formyl alpha -- L -- aspartyl -- L -- phenylalanine synthesis in aqueous phase |
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| WU Jiang,YE Fa-bing.N -- formyl alpha -- L -- aspartyl -- L -- phenylalanine synthesis in aqueous phase[J].Journal of Huanggang Normal University,2013(6):30-31,39. |
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| Authors: | WU Jiang YE Fa-bing |
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| Institution: | 1.Dynamic (Nanjing) Chemical Co., Ltd, Nanjing 210047, Jiangsu, China; 2.College of Chemical Engineering, Huanggang NormalUniversity, Huangzhou 438000, Hubei, China) |
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| Abstract: | Usually acylation of N -- formyl alpha -- L -- aspartic anhydride and L - phenylalanine must be carried out in acetic acid, without water. We added N -- formyl alpha -- L -- aspartic anhydride and liquid alkali in alkaline aqueous solution with L--phenylalanine step by step to achieve acylation process of N -- formyl alpha -- L -- aspartic anhydride and L -- phenylalanine. The result showed that the productive rate of the target compound, N--formyl alpha -- L -- as- partyl -- L - phenylalanine, was 96%. The technology is eco--friendly. |
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| Keywords: | N -- formyl alpha- L -- aspartyl -- L - phenylalanine alkaline aqueous solution acylation |
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