Role of oxidative stress while controlling iron deficiency anemia during pregnancy - Indian scenario |
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| Authors: | Neeta Kumar Nomita Chandhiok Balwan S Dhillon Pratik Kumar |
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| Institution: | (1) Division of Reproductive Health and Nutrition, Indian Council of Medical Research, Ansari Nagar, New Delhi, 110029, India;(2) Department of Medical Physics, IRCH, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India;(3) Div. of RHN, Indian Council of Medical Research, Ansari Nagar, New Delhi, 110029, India |
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| Abstract: | Iron Deficiency anemia ranks 9th among 26 diseases with highest burden. Asia bears 71% of this global burden. Adverse maternal and birth outcome associated
with hemoglobin status renders the issue worth attention. Indian scenario has worsened over the period despite continuous
international and national efforts. This indicates some lacunae in the approach and strategies applied. Various reports state
that even with maximum effort to increase outreach and monitoring for adherence to Iron schedule, consumer’s compliance remains
abysmally low. Recent studies has pointed out biological basis of side effects (gastrointestinal complains and systemic events)
as raised oxidative stress for which iron is the key catalyst. Up till now the only target of research has been to raise hemoglobin
of pregnant women above 11gm/dl. With the reports of pregnancy specific morbidities i.e. hemorrhage and septicemia with low
hemoglobin, eclampsia, small for gestation age, gestational diabetes with higher ranges of hemoglobin, alarm is raised to
define optimum range. Use of oxidative stress as biochemical marker with different doses and schedules has been defined because
India lack information for its own population upon oxidative stress status when iron is supplemented as per current guidelines.
Studies done in India and abroad have defined that too much and too less, both may raise oxidative stress and studies of this
sort may provide biochemical scale for optimization. This review therefore has evaluated currently available Indian research
and reports to understand the need of future research area. Important findings from other countries have been incorporated
for comparison. |
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| Keywords: | Oxidative stress Iron supplementation Anemia during pregnancy |
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