Pharmacokinetics of mycophenolic acid in Chinese kidney transplant patients |
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| Authors: | Lu Xiao-yang Huang Hong-feng Sheng-Tu Jian-zhong and Liu Jian |
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| Institution: | (1) Department of Clinical Pharmacology, First Affiliated Hospital, School of Medicine, Zhejiang University, 310003 Hangzhou, China |
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| Abstract: | To assess the influence of cyclosporin A (CsA) and tacrolimus (FK506) on mycophenolic acid (MPA) and correlation analysis
of the pharmacokinetic parameters and patient characteristics, clinical outcome in Chinese kidney transplant recipients, the
pharmacokinetics of 1000 mg mycophenolate mofetil (MMF) twice daily was measured by high-performance liquid chromatography
(HPLC). PKS (Pharmaceutical Kinctics Software) 1.0.2 software package was used for the calculation of pharmacokinetic parameters.
The meanC
max,t
max, and AUC(0–12) were (21.88±10.52) μg/ml, (1.20±0.95) h, and (52.546±13.215) μg·h/ml, respectively. The level of AUC(0–12) in the FK506 group was significantly higher than that in the CsA group. MPA appeared not to be affected by renal function.
MPA AUC(0–12) showed statistically significant difference according to the patient's gender.
Project (No. 20040462) supported by the Foundation of Education Bureau of Zhejiang Province, China |
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| Keywords: | Mycophenolate mofetil Mycophenolic acid Pharmacokinetics Kidney transplant |
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