| Effect of Mixed Solvents and Additives on the Habit Modification of 6-APA Crystals |
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| 作者姓名： | 龚俊波 王静康 卫宏远 |
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| 作者单位： | SchoolofChemicalEngineeringandTechnology,TianjinUniversity,Tianjin300072,China |
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| 基金项目： | SupportedbyNationalNaturalScienceFoundationofChina(No.20276047). |
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| 摘 要： | 6-aminopenicillanic acid (6-APA) crystals obtained under different physical and chemical conditions of the solutions may present different habits. The habits of diamond-shaped plates are desirable compared with other habits of 6-APA crystals. To obtain ideal 6-APA crystals, the effects of the mixed solvents and additives on 6-APA crystal habits were investigated. Ethanol or acetone was used as the organic solvent, and impurities existing in the ,6-APA purification process were used as the additives. 6-APA growth habits were changed when the concentrations of ethanol, acetone or phenyl acetic acid were increased to exceed their critical concentration. The observed results show that the dominant face on 6-APA crystals was identified to be , {020}, but the overall habit was controlled by the relative growth rates of the : 101 and {002} faces. Crystal growth rates and habits can be appreciably changed by specific adsorption of additives on crystal faces. In some cases solvent molecules can act in a similar way and may be regarded as bulk additives. The effects of additives and organic solvents on 6-APA crystal habits were the results of adsorption effect,which fitted the experimental results quite well.
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| 关 键 词： | 6-APA 结晶体 晶体结构 混合溶剂 添加剂 |
Effect of Mixed Solvents and Additives on the Habit Modification of 6-APA Crystals |
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| GONG Junbo,WANG Jingkang,WEI Hongyuan.Effect of Mixed Solvents and Additives on the Habit Modification of 6-APA Crystals[J].Transactions of Tianjin University,2005,11(3):157-161. |
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| Authors: | GONG Junbo WANG Jingkang WEI Hongyuan |
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| Abstract: | 6-aminopenicillanic acid (6-APA) crystals obtained under different physical and chemical conditions of the solutions may present different habits. The habits of diamond-shaped plates are desirable compared with other habits of 6-APA crystals. To obtain ideal 6-APA crystals, the effects of the mixed solvents and additives on 6-APA crystal habits were investigated. Ethanol or acetone was used as the organic solvent, and impurities existing in the 6-APA purification process were used as the additives. 6-APA growth habits were changed when the concentrations of ethanol, acetone or phenyl acetic acid were increased to exceed their critical concentration. The observed results show that the dominant face on 6-APA crystals was identified to be {020}, but the overall habit was controlled by the relative growth rates of the {101} and {002} faces. Crystal growth rates and habits can be appreciably changed by specific adsorption of additives on crystal faces.In some cases solvent molecules can act in a similar way and may be regarded as bulk additives. The effects of additives and organic solvents on 6-APA crystal habits were the results of adsorption effect, which fitted the experimental results quite well. |
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| Keywords: | 6-aminopenicillanic acid (6-APA) crystal habit mixed solvent additive |
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