| Skp2在膀胱上皮癌中的表达及意义 |
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| 引用本文： | 李朝争,赵金媛,张祥宏,王华玖,白杰,关伟,贾文平.Skp2在膀胱上皮癌中的表达及意义[J].河北北方学院学报(医学版),2007,24(1):25-28. |
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| 作者姓名： | 李朝争 赵金媛 张祥宏 王华玖 白杰 关伟 贾文平 |
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| 作者单位： | 1. 河北邢台矿业集团总医院泌尿外科,河北,邢台,054000
2. 河北医科大学第二附属医院病理科,河北,050000 |
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| 摘 要： | 目的：探讨细胞周期蛋白Skp2表达与膀胱移形细胞癌生物学行为的关系。方法：对73例膀胱移形细胞癌进行组织学分级及分期，另取22例正常膀胱组织作为对照。采用免疫组织化学方法S-P法检测各例组织中Skp2蛋白表达水平。并分析其表达水平与临床病理特征的关系。结果：Skp2蛋白阳性表达率为50．7％（37／73），Skp2蛋白表达与肿瘤组织学分级、病理分期显著相关。结论：Skp2是评估膀胱移形细胞癌恶性程度,估计预后有价值的指标。
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| 关 键 词： | 膀胱移行细胞癌 免疫组织化学 表达 |
| 文章编号： | 1673-1484(2007)01-0025-04 |
The Expression and Significance of Skp2 in Bladder Transitional Cell Carcinomas |
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| LI Chao-zheng,ZHAO Jin-yuan,ZHANG Xiang-hong,et al..The Expression and Significance of Skp2 in Bladder Transitional Cell Carcinomas[J].Journal of Hebei North University:Medical Edition,2007,24(1):25-28. |
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| Authors: | LI Chao-zheng ZHAO Jin-yuan ZHANG Xiang-hong |
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| Institution: | LI Chao-zheng1,ZHAO Jin-yuan1,ZHANG Xiang-hong2,et al1.Department of Obstetrics and Gynecology,General Hospital of Xingtai Mining Company,Xingtai,054000,Hebei,China,2.Department of Pathology,Hebei Medical University,Shijiazhuang,050000,Hebei,China |
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| Abstract: | Objective: To investigate the significance of the protein expression of Skp2 in the progression and prognosis of bladder transitional cell carcinoma.Methods: The pathological stage and histological grade were assessed in the 73 cases with surgically resected bladder transitional cell carcinoma.The normal bladder tissue of twenty-two cases was used as control.The expression of Skp2 was tested by immunohistochemical method,and the related clinical phase and its expression were analyzed.Results: The expression rate of Skp2 was 50.7%.Skp2 expression was related with histological grade and pathological stage of tumors closely.Conclusion: Skp2 are important prognostic factors for patients with bladder transitional cell carcinoma. |
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| Keywords: | Skp2 |
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