Polymorphisms in the genes for coagulation factor II,V, VII in patients undergoing coronary angiography |
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| Authors: | Email author" target="_blank">Xu?Geng?Email author Jin?Guo-dong Fu?Guo-sheng Ma?Ji Shan?Jiang Wang?Jian-an |
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| Institution: | (1) The Second Affiliated Hospital, College of Medicine, Zhejiang University, 310009 Hangzhou, China;(2) Sir Run Run Shaw Hospital, College of Medicine, Medicine, Zhejiang University, 310009 Hangzhou, China |
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| Abstract: | Objective: To determine whether polymorphisms in the genes for coagulation factor. II, V, VII could predispose an individual
to increase risk for coronary artery disease (CAD) and/or myocardial infarction (MI) in Chinese. Methods: We screened coagulation
factor II(G20210A), V(G1691A), VII (R353Q and HVR4) genotype in 374 patients undergoing coronary angiography by polymerase
chain reaction and restriction fragment length polymorphism (PCR-RFLP) assay. Results: The R353Q and HVR4 gemotype of the
factor VII distribution was in accordance with Hardy-Weinberg equilibrium. The frequencies of FVII genotype or allele did
not show statistically significant differences between CAD group and controls or between male and female. The frequencies
of the Q allele and (RQ+QQ) genotype were significantly higher among the CAD patients without myocardial infarction (MI) history
than among those with MI history (P<0.05). However, HVR4 polymorphism was not significantly different within groups. We only find one normal control of factorII
(G20210A) mutation. No coagulation factor V(G1691A) mutation was found in the CAD patients and controls. Conclusion: The factor
II(G20210A), V(G1691A) mutation is absent and may not be a major genetic factor for CAD and/or MI; the Q allele of the R353
Q polymorphism of the factor VII gene may be a protective genetic factor against myocardial infarction in Chinese.
Project (No. 021103166) supported by a grant from the Key Project of Science and Technology Commission of Zhejiang Province,
China |
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| Keywords: | Coagulation factor Polymorphism Coronary angiography Myocardial infarction |
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