| 间,对三氟甲基苯腈的工艺改进 |
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| 作者姓名： | 刘刚 |
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| 作者单位： | 1. 中国科学院新疆理化技术研究所, 乌鲁木齐 830011;
2. 中国科学院研究生院, 北京 100039 |
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| 摘 要： | 间,对三氟甲基苯腈是一种重要的医药、农药中间体.叙述了在一个反应器中利用NiCl2和P(C6H5)3,用还原性金属粉末原位还原生成的Ni((C6H5)3)3作为催化剂,将间、对氯三氟甲苯转化为相应的芳香腈,转化率分别达到87.0%和82.7%.该反应条件温和,易于控制,已经实现工业化生产.
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| 关 键 词： | 间三氟甲基苯腈 对三氟甲基苯腈 间氯三氟甲苯 对氯三氟甲苯 三(三苯基膦)合镍(0) |
| 收稿时间： | 2002-03-09 |
| 修稿时间： | 2002-05-15 |
Process Improvement of m,p-Trifluoromethylbenzonitrile |
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| Authors: | Liu Gang |
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| Institution: | 1. Xinjiang Technology Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumgi 830011;
2. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China |
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| Abstract: | m,p Trifluoromethylbenzonitrile are useful intermediates for synthesis of pharmaceuticals and agricultural chemicals.The article discloses that m, p chlorobenzotrifluoride are converted to m, p trifluoromethylbenzonitrile using Ni(P(C6H5)3)3 as catalyst which give 87.0% and 82.7% conversion respectively. The catalyst is prepared in situ from anhydrous NiCl 2 with PФ 3 in the presence of a reducing powder in a single reactor vessel. The reaction occurs under simple, mild conditions and easily to be controlled and has been carried out in a commercial scale. |
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| Keywords: | m-chlorobenzotrifluoride p-chlorobenzotrifluoride m-trifluoromethylbenzonitrile p-trifluo-romethylbenzonitrile tris(triphenylphosphine)nickel(0) |
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