Leucine amino peptidase a better indicator of carcinoma of liver, biliary tract and pancreas |
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| Authors: | M S Ghadge A V Sirsat M S Bhansali L J Desouza P Jagannath |
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| Institution: | (1) Department of Biochemistry, Tata Memorial Hospital, Parel, 400 012 Mumbai;(2) Department of Gastrointestinal Surgical Oncology, Tata Memorial Hospital, Parel, 400 012 Mumbai;(3) B/2, Gnyanadeep C.H.S., 17th Road, Santacruz (West), 400 054 Mumbai |
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| Abstract: | Serum levels of leucine amino peptidase (LAP) was studied along with bilirubin, aspartate transaminase (AST), alanine transaminase
(ALT), gamma glutamyl transpeptidase (GGT), alkaline phosphatase (ALP) and the ratio of AST/ALT and GGT/AST in 25 healthy
subjects and 52 patients with hepatobiliary malignancies of which 12 were with hepatocellular carcinoma, 12 with liver metastasis,
6 with obstructive jaundice, 9 with carcinoma of gall bladder, 6 with carcinoma of pancreas and 7 with periampullary carcinoma.
24 Of the 52 patients studied had jaundice and 28 were without jaundice.
LAP as compared to the other enzymes AST, ALT, GGT, ALP and AST/ALT ratio and GGT/AST ratio showed 100% elevation in obstructive
jaundice, carcinoma of gall bladder and pancreas and periampullary carcinoma, 91.7% elevation in hepatocellular carcinoma
and 83.3% elevation in liver metastasis. On comparing the levels of these enzymes in non jaundiced and jaundiced groups, LAP
was elevated in both jaundiced and non jaundiced groups in 95.8% and 92.9% cases respectively whereas the other enzymes AST
showed increase from 67.9% to 100%, ALT from 21.4% to 83.3%, GGT from 71.4% to 95.4% and ALP from 82.1% to 100% in non jaundiced
and jaundiced groups respectively indicating that LAP rises in hepatic dysfunction due to hepatobiliary malignancy whereas
the other liver function enzymes showed increased hepatic dysfunction due to hepatobiliary malignancy with the onset of jaundice
thereby indicating that LAP is a better indicator of hepatobiliary malignancy as compared to other enzymes.
The quantitative methods used for determination are reliable, accurate, simple, rapid and cost effective and therefore have
better application in a clinical setting. |
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| Keywords: | Leucine amino peptidase carcinoma liver biliary tract pancreas |
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