A Comparative Study of Bone Scan Findings and Serum Levels of Tumor Marker CA15-3 in Patients with Breast Carcinoma |
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| Authors: | Meera S Ghadge Purva P Naik Bijaynath P Tiwari Ruprekha M Hegde Tanaji J Matale |
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| Institution: | (1) Department of Biochemistry, Tata Memorial Hospital, Parel, Mumbai, 400012, India;(2) B/2 Gnyanadeep CHS, 17th Road, Santacruz West, Mumbai, 400054, India;(3) Radiation Medicine Centre, Tata Memorial Centre, Parel, Mumbai, 400012, India |
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| Abstract: | Breast cancer is one of the most frequent malignancies in the world. Available staging procedures to detect breast cancer
are bone scan, chest X-ray, liver ultrasonography, computerized tomography, estimation of tumor markers like carbohydrate
antigen (CA15-3) and carcino embryonic antigen. These procedures are expensive and may not be required in all cases. Out of
70 patients studied, 55 had normal CA15-3 and 15 had elevated levels of Ca15-3. Eight (14.5%) of the 55 patients with normal
CA15-3 had abnormal bone scan. Fifteen patients had CA15-3 levels above the normal range and among these 9 (60%) had abnormal
bone scan. While prime facie it would appear that a high level of CA15-3 correlate with abnormal bone scan, it is also true
that the numbers are small at present and conclusions about the validity of CA15-3 as marker of bone metastasis may be premature. |
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| Keywords: | Tumor marker Breast cancer CA15-3 Metastasis Bone scan |
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