| Abstract: | Sila-substitution (C/Si-exchange) of drugs is one of the approaches currently used in the search for new biologically active organosilicon compounds. Replacement of specific carbon atoms in drugs by silicon results in changes in chemical and physicochemical properties as well as in the structure. As a consequence, the biological properties, such as pharmacological potency and selectivity and toxicity, may be influenced. Systematic sila-substitution seems to be a useful and efficient strategy in drug design and should be regarded as a complementary tool for the development of new drugs. |
