Cholesterol synthesis and its regulation in acute myocardial infarction |
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| Authors: | Neeta Shenvi Saroj Taskar |
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| Institution: | 1. CVTC Laboratory, Seth G.S. Medical College and KEM Hospital, Parel, 400 012, Bombay, India
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| Abstract: | Cholesterol synthesis and its suppression by LDL was measured in freshly isolated leucocytes from patients with acute myocardial infarction and healthy controls. Cells incubated for different time intervals in lipoprotein-deficient serum exhibited increased cholesterol synthesis. The magnitude of this increase was far greater in leucocytes of hyperlipemic patients than in normolipemic patients. Addition of LDL to the incubation medium produced suppression of cholesterol synthesis. This reduction was less in hyperlipemic patients as compared to normolipemic patients. These observations may imply reduced suppression of HMG-CoA reductase activity with high endogenous cholesterol synthesis in patients suffering with acute myocardial infarction. |
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