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| 运动对胰岛素抵抗大鼠脂肪组织氧化应激及炎症的影响 | |
| 引用本文： | 杨洪涛,李娟,陈巍,李曙刚,高磊,尚宁宁.运动对胰岛素抵抗大鼠脂肪组织氧化应激及炎症的影响[J].西安体育学院学报,2010,27(2). |
| 作者姓名： | 杨洪涛 李娟 陈巍 李曙刚 高磊 尚宁宁 |
| 作者单位： | 1. 河北科技师范学院,体育系,河北,秦皇岛,066044 2. 燕山大学体育系,运动人体科学实验室,河北,秦皇岛,066044 3. 中国人民解放军总医院,军医进修学院,北京,100853 |
| 基金项目： | 河北省科技厅资助课题 |
| 摘 要： | 目的 观察运动对胰岛素抵抗(Insulin Resistance IR)大鼠脂肪组织SOD活性,MDA及TNF-α含量的影响,探讨运动对IR改善的机制.方法 22只雄性SD大鼠随机分为空白对照组6只(CG)、胰岛素抵抗组(IRG)和胰岛素抵抗运动组(EIRG)各8只,采用高脂饲料诱导IR动物模型,EIRG大鼠进行为期10周游泳训练,测定各组大鼠脂肪组织中SOD活性,MDA及TNF-α含量.结果 采用高脂饲料诱导IR模型成功,运动干预后与CG比较,IRG大鼠脂肪组织MDA和TNF-α水平显著升高(P<0.05);与IRG比较,EIRG脂肪组织SOD活性显著提高(P<0.05),MDA和TNF-α水平显著降低(P<0.05);IR指数与MDA,IR指数与TNF-α,MDA与TNF-α均成正相关(r:0.430,P:0.01;r:0.475,P:0.025;r:0.432.P:0.045).结论 运动对大鼠IR的改善机制可能是通过运动上调脂肪组织抗氧化酶活性,进而降低炎性脂肪因子表达实现的. |
| 关 键 词： | 运动 胰岛素抵抗 氧化应激 炎症 |
Effect of Movement on Oxidative Stress and Inflammation of Insulin Resistance Rats' Adipose Tissue |
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| YANG Hong-tao,LI Juan,CHEN Wei,LI Shu-gang,GAO Lei,SHANG Ning-ning.Effect of Movement on Oxidative Stress and Inflammation of Insulin Resistance Rats' Adipose Tissue[J].Journal of Xi'an Institute of Physical Education,2010,27(2). | |
| Authors: | YANG Hong-tao LI Juan CHEN Wei LI Shu-gang GAO Lei SHANG Ning-ning |
| Institution: | YANG Hong-tao1,LI Juan2,CHEN Wei1,LI Shu-gang1,GAO Lei3,SHANG Ning-ning1(1.Department of PE,Hebei Normal University of Science , Technology,Qinhuangdao 066004,China,2.Department of PE of Yanshan University,3.Chinese PLA general hospital Postgraduate medical school,Beijing 100853,China) |
| Abstract: | Objective Observant the effect of exercise on SOD,MDA and TNF-alpha of insulin resistance rats' adipose tissue,in order to investigate the mechanism of exercise improve insulin resistance.Method 22 SD rats were randomly divided into 3 groups: sedentary control group(CG,n=6),insulin resistance group(IRG,n=8) and insulin resistance plus exercise group(EIRG,n=8).The models of insulin resistance were induced by high fat feed,the EIRG rats were subjected to swimming for 10 weeks.Then SOD,MDA and TNF-alpha of all... |
| Keywords: | exercise Insulin resistance Oxidative stress inflammation |
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