| 人体血浆中Tb(Ⅲ)物种的计算机模拟研究 |
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| 引用本文： | 卢兴,张海元,王进平,王悦,杨魁跃,牛春吉,倪嘉缵.人体血浆中Tb(Ⅲ)物种的计算机模拟研究[J].中国科学院研究生院学报,2003,20(1):7-12. |
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| 作者姓名： | 卢兴 张海元 王进平 王悦 杨魁跃 牛春吉 倪嘉缵 |
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| 作者单位： | 中国科学院长春应用化学研究所稀土化学与物理开放实验室,长春,130022 |
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| 基金项目： | supportedbyNationalNaturalAcienceFoundationofChina(2 9890 2 80，2 99710 2 9) |
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| 摘 要： | 建立了人体血浆多相模型,研究了人体血浆体系中Tb(Ⅲ)物种的分布.结果表明,Tb(Ⅲ)的物种形式随着Tb(Ⅲ)的量浓度的变化而变化.当Tb(Ⅲ)的量浓度低于4.000×10-8mol/L时,大部分Tb(Ⅲ)物种以可溶态存在;当Tb(Ⅲ)的量浓度高于4.000×10-8mol/L而低于1.667×10-2mol/L时,沉淀物种(TbPO4和Tb2(CO3)3)成为Tb(Ⅲ)的主要物种.可溶的Tb(Ⅲ)在量浓度低于1.0×10-4mol/L时,主要与运铁蛋白键合,分布于Tb(Tf)]中;当Tb(Ⅲ)的量浓度高于1.0×10-4mol/L时,运铁蛋白耗尽,可溶的Tb(Ⅲ)主要分布于Tb(HSA)],Tb2(Tf)],Tb(Ox)]和Tb(Cit)]等物种中.
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| 关 键 词： | 计算机模拟 物种 人体血浆 Tb(Ⅲ) |
Computer Simulation of Tb( Ⅲ )Speciation in Human Blood Plasma |
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| Abstract.Computer Simulation of Tb( Ⅲ )Speciation in Human Blood Plasma[J].Journal of the Graduate School of the Chinese Academy of Sciences,2003,20(1):7-12. |
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| Authors: | Abstract |
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| Abstract: | A multi-phase model of human blood plasma was developed and the Tb( Ⅲ) specia-tion in this system was studied. The results show that the speciation of Tb( Ⅲ ) depends onthe concentration of Tb( Ⅲ ). When the concentration of Tb( Ⅲ ) is below 4. 000 × 10-8 mol/L,most of Tb ( Ⅲ ) exists as soluble species while the concentration of Tb ( Ⅲ ) is in between4. 000× 10-8 mol/L and 1. 667 × 10-2 mol/L, precipitates (TbPO4 and Tb2 (CO3)3) are thedominant species of Tb(Ⅲ). Among soluble Tb(Ⅲ) species, Tb( Ⅲ) is mostly bound to thetransferrin to form Tb(Tf)] when the concentration of soluble Tb(Ⅲ) is below 1.0 × 10 4mol/L. The concentration of soluble Tb(Ⅲ) reaches 1.0 × 10-4mol/L, thus available trans-ferrin is exceeded, and soluble Tb(Ⅲ) ions mainly distribute in Tb(HSA)], Tb2 (Tf)],Tb(Ox)] and Tb(Cit)] etc. |
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| Keywords: | computer simulation speciation human blood plasma |
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