| Expression and significance of cyclin D1, p27kip1 protein in bronchioloalveolar carcinoma |
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| 作者姓名： | 袁键群 许敬尧 张静 何启才 祝佳 盛彩霞 |
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| 作者单位： | Sir Run Run Shaw Hospital，School of Medicine，Zhejiang University，Hangzhou 310016，China，Sir Run Run Shaw Hospital，School of Medicine，Zhejiang University，Hangzhou 310016，China，Sir Run Run Shaw Hospital，School of Medicine，Zhejiang University，Hangzhou 310016，China，Sir Run Run Shaw Hospital，School of Medicine，Zhejiang University，Hangzhou 310016，China，Sir Run Run Shaw Hospital，School of Medicine，Zhejiang University，Hangzhou 310016，China，Sir Run Run Shaw Hospital，School of Medicine，Zhejiang University，Hangzhou 310016，China |
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| 摘 要： | INTRODUCTION Bronchioloalveolar carcinoma (BAC) is a par-ticular subtype of pulmonary adenocarcinoma de-rived from clara cell and type II pneumocyte. BAC cells grow along and within alveolar spaces while the alveolar framework of the lung is preserved. The incidence of BAC appears to be rising recently. The etiology and pathogenesis of this unique neoplastic disease are still unclear; many studies of oncogene and tumor suppressor gene expression include BAC with all adenocarcinoma o…
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Expression and significance of cyclin D1, p27kip1 protein in bronchioloalveolar carcinoma |
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| YUAN Jian-qun,XU Jing-yao ,ZHANG Jing,HE Qi-cai,ZHU Jia,SHENG Cai-xia.Expression and significance of cyclin D1, p27kip1 protein in bronchioloalveolar carcinoma[J].Journal of Zhejiang University Science,2004(2). |
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| Authors: | YUAN Jian-qun XU Jing-yao ZHANG Jing HE Qi-cai ZHU Jia SHENG Cai-xia |
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| Abstract: | Purpose: To investigate the relationship between expression of cell cycle-related protein cyclin D1, p27kip1 and the pathogenesis of bronchioloalveolar carcinoma (BAC) and the value of prediction of prognosis. Methods: Cyclin D1 and p27kip1 protein were detected by immunohistochemical En Vision method in 43 BACs. Results: The positivity of cyclin D1 in BAC was 65.1% (28/43), which was significantly higher than that in normal pulmonary tissue (0/13), P<0.01. No statis-tically significant association was found between cyclin D1 expression data and sex, age, tobacco-use history, histologic subtype (mucinous vs nonmucinous), stromal fibrosis, lymph node metastasis, clinical stage or postoperative survival period (P>0.05), while cyclin D1 expression was found to be negatively correlated with tumor size (P<0.05). The positivity of p27kip1 in BACs was 51.2% (22/43), significantly lower than that in normal pulmonary tissue (12/13), P<0.01. p27kip1 expression level was not associated with sex, age, tobacco-use history, tumor size or histologic subtype (P>0.05), but was negatively correlated with stromal fibrosis, lymph node metastasis and clinical stage (P<0.05); and positively associated with postoperative survival period (P<0.01). The survival rate of p27kip1 positive group was significantly higher than that of p27kip1 negative group (P<0.01). No statistically significant correlation was found between cyclin D1 and p27kip1 expres-sion. Conclusions: Increased cyclin D1 expression and decreased p27kip1 expression are related to the pathogenesis of BAC; decreased p27kip1 expression is associated with metastasis progression; immunodetection of p27kip1 is useful for assessment of prognosis. |
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| Keywords: | Adenocarcinoma Bronchioloalveolar Lung neoplasms Cyclin D1 p27kip1 Immunohistochemistryction |
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