| DNA纳米技术与生物编程 |
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| 引用本文： | 李娜等.DNA纳米技术与生物编程[J].中国科学院院刊,2014,29(1):55-69. |
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| 作者姓名： | 李娜等 |
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| 作者单位： | [1]中科院／教育部国家纳米科学中心北京100190 [2]美国亚利桑那州立大学坦佩市85287 |
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| 基金项目： | 基金项目：国家自然科学基金（21222311）,中科院“百人计划”项目 |
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| 摘 要： | DNA纳米技术是设计和构建具有一定用途的人工核酸纳米结构。DNA纳米技术中的一个重要挑战就是如何有效设计和构建具有明确功能的纳米尺度的结构和器件。计算机辅助工具是预测、设计、建模以及描绘DNA结构的最强有力的工具。计算机辅助设计DNA结构以及识别有效的自组装路径让DNA作为一种独特的材料在构建纳米结构领域中显露锋芒。文章总结了DNA纳米结构设计的原理,介绍了一些用于DNA结构设计的算法以及一些用户友好软件。同时,对DNA纳米技术中构建DNA逻辑门以及DNA计算方面的最新研究进展做了介绍。
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| 关 键 词： | DNA纳米技术 人工核酸纳米结构 化学自组装 计算机辅助设计 生物编程 |
| 修稿时间： | 2013/11/6 0:00:00 |
DNA Nanotechnology and Bio-Programming |
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| Li Na Ding Baoquan Yan Hao.DNA Nanotechnology and Bio-Programming[J].Bulletin of the Chinese Academy of Sciences,2014,29(1):55-69. |
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| Authors: | Li Na Ding Baoquan Yan Hao |
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| Institution: | Li Na Ding Baoquan Yan Hao 2 ( 1 National Center for Nanoscience and Technology, Beijing 100190, China 2 Department of Chemistry and Biochemistry, Arizona State University, Tempe AZ 85287-1604, USA) |
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| Abstract: | DNA nanotechnology is the design and manufacture of artificial nucleic acid structures for technolog- ical uses. A central challenge of DNA nanotechnology is to efficiently design and construct well-defined func- tional structures and devices at the nano scale. Computational tools are the most powerful means of predicting, designing, modeling, and characterizing nucleic acid structure. Computer-aided design of nucleic acid structure and the identification of efficient self-assembly pathways have revealed nucleic acids as unique material for the construction of nano-components. In this review, we have summarized the principles of the DNA nanostruc- tures design, and introduced some algorithms and user-friendly software for nucleic acid design. Meanwhile, the recent progress in DNA logic gates and DNA computing is also included |
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| Keywords: | DNA nanotechnology artificial nucleic acid structure computer-aided design bio-programming |
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