Protective effects of Salvia miltiorrhizae on the hearts of rats with severe acute pancreatits or obstructive jaundice |
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| Authors: | Xi-ping Zhang Guang-hua Feng Jie Zhang Yang Cai Hua Tian Xiao-feng Zhang Yi-feng Zhou Zhi-wei Wang Ke-yi Wang |
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| Institution: | (1) Department of General Surgery, Hangzhou First People’s Hospital, Hangzhou, 310006, Zhejiang Province, China;(2) Department of General Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, Zhejiang Province, China;(3) Zhejiang University of Traditional Chinese Medicine, Hangzhou, 310053, Zhejiang Province, China;(4) Centralab, Hangzhou First People’s Hospital, Hangzhou, 310006, Zhejiang Province, China |
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| Abstract: | Objective To investigate the therapeutic effects and mechanisms of Salvia miltiorrhizae (Danshen) in the treatment of severe acute pancreatitis (SAP)- or obstructive jaundice (OJ)-induced heart injury.
Methods A total of 288 rats were used for SAP- (n=108) and OJ-associated (n=180) experiments. The rats were randomly divided into sham-operated, model control, and Salvia miltiorrhizae-treated groups. According to the difference of time points after operation, SAP rats in each group were subdivided into 3,
6 and 12 h subgroups (n=12), whereas OJ rats were subdivided into 7, 14, 21, and 28 d subgroups (n=15). At the corresponding time points after operation, the mortality rates of the rats, the contents of endotoxin and phospholipase
A2 (PLA2) in blood, and pathological changes of the hearts were investigated.
Results The numbers of dead SAP and OJ rats in the treated groups declined as compared with those in the model control group, but
not significantly (P>0.05). The contents of endotoxin (at 6 and 12 h in SAP rats and on 7, 14, 21, and 28 d in OJ rats, respectively) and PLA2 (at 6 and 12 h in SAP rats and on 28 d in OJ rats, respectively) in the treated group were significantly lower than those
in the model control group (P<0.01 and P<0.001, respectively). Besides, myocardial pathological injuries were mitigated in SAP and OJ rats.
Conclusion In this study, we found that Salvia miltiorrhizae improved myocardial pathological changes, reduced the content of PLA2 in blood, and decreased the mortality rates of SAP and OJ rats, exerting protective effects on the hearts of the rats.
Projected supported by the Technological Foundation Project of Traditional Chinese Medicine Science of Zhejiang Province (Nos.
2003C130 and 2004C142), the Grave Foundation Project for Technological and Development of Hangzhou City (No. 2003123B19),
and the Intensive Foundation Project for Technology of Hangzhou City (No. 2004Z006), China |
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| Keywords: | Salvia miltiorrhizae Traditional Chinese medicine Severe acute pancreatitis (SAP) Obstructive jaundice (OJ) Heart |
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