Effect of ethanolic leaf extract of <Emphasis Type="Italic">Trianthema portulacastrum</Emphasis> L. On aflatoxin induced hepatic damage in rats |
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| Authors: | G Sharmila Banu G Kumar A G Murugesan |
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| Institution: | (1) Phytochemical, Pharmacological and Microbiological Laboratory, Department of Biosciences, Saurashtra University, Rajkot, 360005, Gujarat, India; |
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| Abstract: | The aim of this study was to investigate the ethanolic leaf extract of Trianthema portulacastrum L. (Family: Aizoaceae) on
aflatoxin induced hepatic damage in rats. Aflatoxin intoxication in rats significantly (p < 0.001) elevated the levels of
serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP),
and total bilirubin, which indicated acute hepatocellular damage and biliary obstruction. Ethanolic leaf extract of T. portulacastrum
showed dose dependent decrease in the levels of SGPT, SGOT, ALP and total bilirubin. Minimum effective dose of extract was
found to be 100 mg/kg body weight. Results obtained from histopathological studies also supported hepatoprotective activity
against aflatoxin-induced hepatotoxicity. Thus the study demonstrates that T. portulacastrum possess antihepatotoxic effect
against aflatoxin. |
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