| A SIMPLE METHOD FOR CHIRAL RESOLUTION OF 1,1'-BI-2-NAPHTHOL |
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| 作者姓名： | 李晓桃 蒋珖珖 陈卫祥 徐铸德 |
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| 作者单位： | Department of Chemistry，Zhejiang University，Hangzhou 310027，China |
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| 摘 要： | ＩＮＴＲＯＤＵＣＴＩＯＮＣ2 ｃｈｉｒａｌ 1 ,1’ ｂｉ 2 ｎａｐｈｔｈｏｌ 1ｏｃｃｕｐｉｅｓａｐｏｓｉｔｉｏｎｏｆｐｒｉｍｅｉｍｐｏｒｔａｎｃｅｉｎａｗｉｄｅｒａｎｇｅｏｆｅｎａｎｔｉｏｓｅｌｅｃｔｉｖｅｒｅａｃｔｉｏｎｓ.Ｉｔｐｌａｙｓａｎｉｍｐｏｒｔａｎｔｒｏｌｅｉｎａｓｙｍｍｅｔｒｉｃｓｙｎｔｈｅｓｅｓｗｉｔｈｖｅｒｙｈｉｇｈｅｎ ａｎｔｉｏｍｅｒｉｃｐｕｒｉｔｙ.Ｒｅｌｅｖａｎｔｌｉｔｅｒａｔｕｒｅｒｅｐｏｒｔｓｓｅｖｅｒａｌｍｅｔｈｏｄｓｆｏｒｔｈｅｐｒｅｐａｒａｔｉｏｎｏｆｏｐｔｉｃａｌ…
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A SIMPLE METHOD FOR CHIRAL RESOLUTION OF 1,1'-BI-2-NAPHTHOL |
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| LI Xiao\|tao,JIANG Guang\|guangCHEN Wei\|xiang,XU Zhu\|deWT.,.BZ\%.A SIMPLE METHOD FOR CHIRAL RESOLUTION OF 1,1''''-BI-2-NAPHTHOL[J].Journal of Zhejiang University Science,2001(3). |
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| Authors: | LI Xiao\|tao JIANG Guang\|guangCHEN Wei\|xiang XU Zhu\|de[WT BZ]\% |
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| Institution: | LI Xiao\|tao,JIANG Guang\|guangCHEN Wei\|xiang,XU Zhu\|de[WT9.,10.BZ]\% |
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| Abstract: | An improved method for preparing enantiomerically pure 1,1'\|bi\|2\|naphthols is described. 1,1'\|bi\|2\|naphthol boric anhydride was generated from the reaction of racemic 1,1'\|bi\|2\|naphthol and boric anhydride. Its two diastereoisomers could be efficiently separated in THF using (L)\|proline as the resolving agent. Treatment in three successive steps yielded 79% and 74% enantiomerically pure (S)\| and (R)\|1,1'\|bi\|2\|naphthol respectively. |
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| Keywords: | bi\|2\|naphthol chiral resolution |
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