| 槐定碱抗心律失常作用的实验研究 |
| |
| 引用本文： | 谢世荣,黄彩云,黄胜英.槐定碱抗心律失常作用的实验研究[J].大连大学学报,2002,23(6):104-107. |
| |
| 作者姓名： | 谢世荣 黄彩云 黄胜英 |
| |
| 作者单位： | 大连大学医学院,辽宁,大连,116622 |
| |
| 摘 要： | 槐定碱(Sophoridine,Sop)10mg/kg、20mg/kg能明显对抗乌头碱20μg/kg,,BaCl2和结扎左冠状动脉前降支诱发大鼠的室性心律失常.Sop也能明显对抗CaCl2-Ach(CaCl20.6％+Ach 0.0025％)混合液诱发小鼠心房纤颤或扑动.Sop 10mg/kg对大鼠心电图实验,证明有负性频率作用,负性传导作用.这些作用可能是Sop抗心律失常作用的药理基础.
|
| 关 键 词： | 槐定碱 奎尼丁 乌头碱 氯化钡 心律失常 |
| 文章编号： | 1008-2395(2002)06-0104-04 |
| 修稿时间： | 2002年1月20日 |
Antiarrhythnic effect of saponines of leaf of sophoridine, (Sop) |
| |
| XIE Shi-rong,HUANG Cai-yun,HUANG Sheng-ying.Antiarrhythnic effect of saponines of leaf of sophoridine, (Sop)[J].Journal of Dalian University,2002,23(6):104-107. |
| |
| Authors: | XIE Shi-rong HUANG Cai-yun HUANG Sheng-ying |
| |
| Abstract: | Sophoridine(Sop) 10mg/kg, 20mg/kg could inhibit markedly the ventricular arrhythmias induced by aconitine 20 μg/kg and BaCl2 2 mg/kg and coronary ligation in rat. It also obviously reduced the incidence of atrium fibrillation produced by CaCl2 Ach (CaCl20.6%+Ach 0.0025%) 10 mg/kg in mice. These actions were similar to Quinidine. The ECG of rates was significantly P-R changed after i. v of Sop 10mg/kg. Hearts are reduced. The P-R and Q-T intervals are prolonged. |
| |
| Keywords: | Sop Quinidine Aconitine BaCl2 arrhythmias |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
