| 胶束电动色谱在线富集技术测定那格列奈中的痕量杂质 |
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| 引用本文： | 田宝娟,阎宏远,乔凤霞,杨更亮.胶束电动色谱在线富集技术测定那格列奈中的痕量杂质[J].保定师专学报,2004,17(2):16-18,24. |
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| 作者姓名： | 田宝娟 阎宏远 乔凤霞 杨更亮 |
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| 作者单位： | [1]保定师范专科学校化学系，河北保定071051 [2]河北大学药学院，河北保定071002 |
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| 摘 要： | 利用在线推扫富集技术建立了毛细管电色谱测定新药那格列奈中痕量杂质的方法．考察了缓冲溶液pH值、SDS浓度、运行电压以及进样时间对富集效果的影响．结果表明，那格列奈中的痕量组分富集和检测的最佳缓冲溶液组成为16mmol／L NaH2PO4 6mmol／L Na2B4O7 60mmol／L SDS(pH=7．14)，进样时间为200秒．在最佳条件下对那格列奈进行了痕量杂质测定，那格列奈中的杂质总含量为0．56％．本方法可用于药物的质量控制。
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| 关 键 词： | 毛细管电色谱 在线推扫富集技术 那格列奈 痕量杂质 |
| 文章编号： | 1008-4584(2004)02-0016-03 |
Determination of Impurity in Nategl inide by On -line Sweeping Technique in MEKC |
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| TIAN Bao-juan ,YAN Hong-yuan ,QIAO Feng-xia ,YANG Geng-liang.Determination of Impurity in Nategl inide by On -line Sweeping Technique in MEKC[J].Journal of Baoding Teachers College,2004,17(2):16-18,24. |
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| Authors: | TIAN Bao-juan YAN Hong-yuan QIAO Feng-xia YANG Geng-liang |
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| Institution: | TIAN Bao-juan 1,YAN Hong-yuan 2,QIAO Feng-xia 2,YANG Geng-liang 2 |
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| Abstract: | In this work,an on -line sweeping technique for the determination of trace impurity in nateglinide by using SDS buffer solu tion was developed.The effects of bu ffer pH value,SDS concentra-tion,running voltage and injection time on the signal intensities were i nvestigated.The result shows that the optimum detection conditions of trace impurity in nateglinide were16mmol /L NaH 2 PO 4 +6mmol /L Na 2 B 4 O 7 +60mmol /L SDS (pH =7.14)],injection time andworking voltage.Un-der these conditions,the total trac e impurity of nateglinidehad been detected.This method could be used for the quality control and pharmaceutical analysis. |
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| Keywords: | MEKC On -line sweeping techniques nateglinide trace impurity |
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