| 吗啡耐受过程中大鼠脑内P物质的变化 |
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| 引用本文： | 董孝国.吗啡耐受过程中大鼠脑内P物质的变化[J].商丘师范学院学报,2006,22(2):150-152. |
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| 作者姓名： | 董孝国 |
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| 作者单位： | 商丘师范学院,生物系,河南,商丘,476000 |
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| 基金项目： | 致谢：本文承蒙北京大学生命科学学院“生物膜和膜生物工程国家重点实验室”教授、博士生导师于龙川老师提供实验材料.并指导斧正.在此深表感谢! |
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| 摘 要： | 研究P物质在大鼠吗啡耐药之前后脑内的变化.在未用吗啡的大鼠侧脑室内注射5 nmol P物质和在吗啡耐受后的大鼠侧脑室内注射5nmol P物质都能产生止痛效应,但在同样的剂量下,止痛作用比对未用吗啡耐受性的大鼠要小得多.用免疫组织化学法测试,下丘脑和伏核中P物质免疫反应呈顺调节(下调节),而中脑导管(PAG)周围呈逆调节(上调节).研究表明,具吗啡耐受大鼠脑中P物质诱导的止痛作用相似的免疫反应说明P物质起着重要作用.
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| 关 键 词： | 止痛作用 P物质 下丘脑 免疫组化 |
| 文章编号： | 1672-3600（2006）02-0150-03 |
| 收稿时间： | 2005-08-27 |
| 修稿时间： | 2005-11-23 |
Changes of P material in rat brain in morphine tolerance course |
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| DONG Xiao-guo.Changes of P material in rat brain in morphine tolerance course[J].Journal of Shangqiu Teachers College,2006,22(2):150-152. |
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| Authors: | DONG Xiao-guo |
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| Institution: | Biology Department, Shangqiu Teachers College, Shangqiu 476000, China |
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| Abstract: | This text investigated changes of P material in hindbrain before morpine tolerance in rats.After injection of 5 nmol of P material in intracerebrovantricular,antinociceptive effect was engendered in both opioid-naive rats and rats with morphine tolerance.And the later was lower than the former at the same dosage.At the same time,there was downregulation of P material inmmunoreactivity in both hypothalamus and central nucleus of amygdala tested by immunohistochemical methods.whereas there was upregulation around periaqueductal gray(PAG).This study demonstrated:the immunoreaction that was similar with the antinociceptive effect induced by P material in rat brain after morphine tolerance suggesting that P material may play an important part in morphine tolerance. |
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| Keywords: | antinociceptive effect P material hypothalamus immunohistochemistry |
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