The response of liver lipid peroxidative and antioxidant defense systems of protein undernourished rats to liver regeneration |
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| Authors: | Gbenga Adebola Adenuga Olusegun Lateef Adebayo Bukunola Oluyemisi Adegbesan |
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| Institution: | (1) Department of Biochemistry, Olabisi Onabanjo University, Remo campus, P.M.B. 2005, Ikenne, Ogun State, Nigeria |
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| Abstract: | The response of liver lipid peroxidative and antioxidant defense system of protein undernourished rats to liver regeneration
induced by partial hepatectomy was examined in rats. Animals were divided into four groups; A,B,C and D of four animals each.
Animals in group A were maintained on 16% casein diet while those in groups B, C and D were placed on low-protein diet (5%
casein) for fourteen weeks and fed ad libitum. 72 hours before sacrifice, partial hepatectomy was carried out on animals in
group D while animals in group C were sham-operated. The results show that protein undernutrition induced an increase in lipid
peroxidation but reduced catalase activity, glutathione level and superoxide dismutase activity when compared with well-nourished
rats. Liver regeneration however, resulted in significant increases in lipid peroxidation and catalase activity but significant
reductions in glutathione level and superoxide dismutase activity in protein undernutrition rats when compared with their
sham-operated counterparts. These results suggest that liver regeneration induced by partial hepatectomy exacerbates lipid
peroxidation in protein undernutrition rats and that Catalase plays a major role in the mopping up of reactive oxygen species
generated following liver regeneration in partially hepatectomised protein undernutrition rats. |
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| Keywords: | Lipid peroxidation Antioxidants Protein-undernutrition Liver regeneration Partial hepatectomy |
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