Institution: | 1. Center for Autism Research, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA;2. Center for Autism Research, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania, USA;3. Bryn Mawr College, Bryn Mawr, Pennsylvania, USA;4. University of Texas at Dallas, Richardson, Texas, USA;5. National Institute of Mental Health and Neurosciences, Bangalore, India;6. Department of Speech and Hearing Sciences, University of Washington, Seattle, Washington, USA;7. Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA;8. Center for Autism Research, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA;9. The James S. McDonnel Foundation, Saint Louis, Missouri, USA;10. University of North Carolina, Chapel Hill, North Carolina, USA;11. Department of Pediatrics, University of Alberta, Edmonton, Alberta, USA |
Abstract: | Infant vocalizations are early-emerging communicative markers shown to be atypical in autism spectrum disorder (ASD), but few longitudinal, prospective studies exist. In this study, 23,850 infant vocalizations from infants at low (LR)- and high (HR)-risk for ASD (HR-ASD = 23, female = 3; HR-Neg = 35, female = 13; LR = 32, female = 10; 80% White; collected from 2007 to 2017 near Philadelphia) were analyzed at 6, 12, and 24 months. At 12 months, HR-ASD infants produced fewer vocalizations than HR-Neg infants. From 6 to 24 months, HR-Neg infants demonstrated steeper vocalization growth compared to HR-ASD and LR infants. Finally, among HR infants, vocalizing at 12 months was associated with language, social phenotype, and diagnosis at age 2. Infant vocalizing is an objective behavioral marker that could facilitate earlier detection of ASD. |